.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,910,592

« Back to Dashboard

Details for Patent: 5,910,592

Title: Substituted thiazolidinedione derivatives
Abstract:A compound of formula (I): ##STR1## wherein: R.sup.1 represents a hydrogen atom, C.sub.1-12 alkyl, C.sub.1-12 alkoxy, C.sub.1-12 alkylcarbonyl or arylC.sub.1-12 alkyl; A.sup.1 represents hydrogen or 1 to 4 optional substituents selected from the group consisting of: C.sub.1-12 alkyl, C.sub.1-12 alkoxy, aryl and halogen; aryl represents phenyl or naphthyl optionally substituted with up to five groups selected from halogen, C.sub.1-12 alkyl, phenyl, C.sub.1-12 alkoxy, haloC.sub.1-12 alkyl, hydroxy, nitro, C.sub.1-12 alkoxycarbonyl, C.sub.1-12 alkoxycarbonyl C.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonyloxy, or C.sub.1-12 alkylcarbonyl; A.sup.2 represents a benzene ring having 1 to 3 optional substituents selected from hydrogen, halogen, C.sub.1-12 alkyl, C.sub.1-12 alkoxy; and M.sup.- represents a counter-ion other than the maleate ion.
Inventor(s): Pool; Colin Ripley (Cranleigh, GB), Roman; Robin Sherwood (Fetcham, GB), Brightwell; Malcolm David (Redhill, GB), Tremper; Alan William (Edenbridge, GB)
Assignee: SmithKline Beecham plc (Brentford, GB)
Filing Date:Jul 14, 1997
Application Number:08/892,045
Claims:1. A compound of formula (I): ##STR7## or a tautomeric form thereof,wherein: R.sup.1 represents a hydrogen atom, C.sub.1-12 alkyl, C.sub.1-12 alkoxy, C.sub.1-12 alkylcarbonyl or arylC.sub.1-12 alkyl;

A.sup.1 represents hydrogen or 1 to 4 optional substituents selected from the group consisting of: C.sub.1-12 alkyl, C.sub.1-12 alkoxy, aryl and halogen;

aryl represents phenyl or naphthyl optionally substituted with up to five groups selected from halogen, C.sub.1-12 alkyl, phenyl, C.sub.1-12 alkoxy, haloC.sub.1-12 alkyl, hydroxy, nitro, C.sub.1-12 alkoxycarbonyl, C.sub.1-12 alkoxycarbonyl C.sub.1-12 alkoxycarbonyloxy, or C.sub.1-12 alkylcarbonyl;

A.sup.2 represents a benzene ring having 1 to 3 optional substituents selected from hydrogen, halogen, C.sub.1-12 alkyl, C.sub.1-12 alkoxy; and

M.sup.- represents a counter-ion other than the maleate ion.

2. A process for the preparation of a compound of formula (I) according to claim 1, or a tautomeric form thereof, which process comprises reacting a compound of formula (II): ##STR8## wherein R.sup.1 , A.sup.1 and A.sup.2 are as defined in relation to formula (I) in claim 1, with a source of counter-ion M- which is defined in relation to formula (I), as defined in claim 1.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc