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|Title:||Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers|
|Abstract:||A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that referentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (-)-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.|
|Inventor(s):||Liotta; Dennis C. (McDonough, GA), Schinazi; Raymond F. (Decatur, GA), Choi; Woo-Baeg (North Brunswick, NJ)|
|Assignee:||Emory University (Atlanta, GA)|
|Filing Date:||Jul 14, 1998|
|Claims:||1. A method for the resolution of the combination of enantiomers of cis-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane comprising passing the cis-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane through an acetylated .beta.-cyclodextrin chiral column and obtaining the (+) and (-) enantiomers of cis-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane.|
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