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Generated: April 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,892,025

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Title: Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
Abstract:A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that referentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (-)-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.
Inventor(s): Liotta; Dennis C. (McDonough, GA), Schinazi; Raymond F. (Decatur, GA), Choi; Woo-Baeg (North Brunswick, NJ)
Assignee: Emory University (Atlanta, GA)
Filing Date:Jul 14, 1998
Application Number:
Claims:1. A method for the resolution of the combination of enantiomers of cis-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane comprising passing the cis-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane through an acetylated .beta.-cyclodextrin chiral column and obtaining the (+) and (-) enantiomers of cis-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane.

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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
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Merck
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Federal Trade Commission

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