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|Abstract:||The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting 2-amino-6-chloropurine (ACP) with an appropriate side chain precursor, followed by conversion of the 6-chloro moiety to a hydroxy moiety (i.e. to form a guanine) or hydrogen (to form a 2-aminopurine), respectively; and 2-acetoxymethyl-4-halo-butyl-1-yl acetates.|
|Inventor(s):||Geen; Graham Richard (Stansted Mountfichet, GB2), Jarvest; Richard Lewis (Surbiton, GB2)|
|Assignee:||SmithKline Beecham plc (Brentford, GB2)|
|Filing Date:||Jun 30, 1997|
|Claims:||1. A compound known as 2-acetoxymethyl-4-halo-but-1-yl acetate. |
2. A compound according to claim 1 wherein halo is bromo.
3. A compound according to claim 1 wherein halo is iodo.
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