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|Title:||Dry mix formulation for bisphosphonic acids|
|Abstract:||Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by direct compression/dry mix tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.|
|Inventor(s):||Bechard; Simon R. (Quebec, CA), Kramer; Kenneth A. (Green Lane, PA), Katdare; Ashok V. (Norristown, PA)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
|Filing Date:||Oct 08, 1997|
|Claims:||1. A pharmaceutical composition comprising by weight, about 0.5 to 40% by weight of an active ingredient selected from the group consisting of: |
1-hydroxy-2-[3-pyridyl]ethylidene-1,1-bisphosphonic acid; and
or a pharmaceutically acceptable salt thereof; and from about 60 to 99.5% by weight of excipients comprising:
a diluent, a binder, a disintegrant, and a lubricant.
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