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Generated: February 23, 2018

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Title: Sustained release formulations of water soluble peptides
Abstract:The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
Inventor(s): Bodmer; David (Klingnau, CH), Fong; Jones W. (Parsippany, NJ), Kissel; Thomas (Staufen, DE), Maulding; Hawkins V. (Mendham, NJ), Nagele; Oskar (Sissach, CH), Pearson; Jane E. (Ogdensburg, NJ)
Assignee: Novartis AG (Summit, NJ)
Filing Date:Jun 06, 1995
Application Number:08/470,907
Claims:1. A process for the production of microparticles comprising ostreotide distributed throughout, which comprises intensively mixing:

a) a solution of octreotide in a weight/volume ratio of 2.5 g/10 ml in a buffer of pH 3-8 and

b) a solution of a polylactide-co-glycolide in methylene chloride in a weight/volume ratio of 40 g/100 ml in such a manner that the weight/weight ratio of the drug to the polymer is 1/16 and the volume/volume ratio of the aqueous medium/organic solvent is 1/10, intensively mixing the w/o-emulsion of a) in b) together with

c) an excess of a buffer of a pH 3-8, containing gelatine in a concentration of 0.5% of weight at a volume/volume mixing speed ratio of ab)/c) of 1/40, without adding any drug retaining substance to the water-in-oil emulsion or applying any intermediate viscosity increasing step, hardening the embryonic microparticles in the formed w/o/w-emulsion by evaporation of the methylene chloride and by isolating, washing and drying the generated microparticles.
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