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Serving hundreds of leading biopharmaceutical companies globally:

Accenture
Teva
McKesson
Deloitte
Baxter
Fish and Richardson
Dow
Express Scripts
US Department of Justice

Generated: April 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,872,130

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Title: Quinoline type mevalonoactones
Abstract:Described herein are mevalonolactone derivatives having a quinoline ring of formula (I) ##STR1## wherein the R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Y and Z variables are described therein.
Inventor(s): Fujikawa; Yoshihiro (Funabashi, JP), Suzuki; Mikio (Funabashi, JP), Iwasaki; Hiroshi (Funabashi, JP), Sakashita; Mitsuaki (Shiraoka-machi, JP), Kitahara; Masaki (Shiraoka-machi, JP)
Assignee: Nissan Chemical Industries Ltd. (Tokyo, JP)
Filing Date:Dec 19, 1990
Application Number:07/631,092
Claims:1. A compound of the formula ##STR16## wherein c-Pr is cyclopropyl, and Z is --CH(OH)--CH.sub.2 --CH(OH)--CH.sub.2 --COOH, --CH(OH)--CH.sub.2 -- CH(OH)--CH.sub.2 --COONa, --CH(OH)--CH.sub.2 --CH(OH)--CH.sub.2 --COOR (wherein R is C.sub.1-3 alkyl), or ##STR17##

2. An anti-hyperlipidemia agent containing the compound of the formula A as defined in claim 1.

3. An anti-hyperlipoproteinemia agent containing the compound of the formula A as defined in claim 1.

4. An anti-atherosclerosis agent containing the compound of the formula A as defined in claim 1.

5. A method for reducing hyperlipidemia, hyperlipoproteinemia or atherosclerosis, which comprises administering an effective amount of the compound of formula A as defined in claim 1.

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Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
Chubb
Healthtrust
Chinese Patent Office
AstraZeneca
Mallinckrodt
Cipla
Fuji
Cerilliant

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