Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson

Generated: May 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,869,670

« Back to Dashboard

Title: 7-(4-aminomethyl-3-me thyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8 -naphthyridine-3-carboxylic acid and the process for the preparation thereof
Abstract:The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4 -oxo-1,4-dihydro-1,8-naphthyridine -3-carboxylic acid represent by the following formula: ##STR1## or its isomer.
Inventor(s): Hong; Chang Yong (Daejon, KR), Kim; Young Kwan (Daejon, KR), Kim; Se Ho (Daejon, KR), Chang; Jay Hyok (Daejon, KR), Choi; Hoon (Daejon, KR), Nam; Do Hyun (Daejon, KR), Kim; Ae Ri (Daejon, KR), Lee; Jin Hwa (Daejon, KR), Park; Ki Sook (Daejon, KR)
Assignee: LG Chemical Ltd. (Seoul, KR)
Filing Date:Mar 27, 1998
Application Number:
Claims:1. A process for preparing 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4 -oxo-1,4-dihydro-1,8-naphthyridine- 3-carboxylic acid represented by the following formula: ##STR271## or its isomer, methanesulfonate and hydrate of the methanesulfonate, which comprises reacting a quinolone compound represented by the following formula, ##STR272## in which X represents a halogen, with a protected pyrrolidine oxime compound represented by the following formula, ##STR273## in which P represents an amino-protecting group, in the presence of a base and then removing the amino-protecting group P from the resulting compound.

2. The process of claim 1, wherein the amino-protecting group is selected from the group consisting of formyl, acetyl, trifluoroacetyl, benzoyl, para-nitrobenzoyl, para-toluenesulfonyl, methoxycarbonyl, ethoxycarbonyl, t-butoxycarbonyl, benzyloxycarbonyl, para-methoxybenzyloxycarbonyl, trichloroethoxycarbonyl, benzyl, para-methoxybenzyl, trityl and tetrahydropyranyl.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Boehringer Ingelheim
Cantor Fitzgerald
US Department of Justice

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.