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|Title:||High affinity nucleic acid ligands of CD4|
|Abstract:||Methods are described for the identification and preparation of high-affinity nucleic acid ligands to CD4. Included in the invention are specific 2'F RNA ligands to CD4 identified by the SELEX method.|
|Inventor(s):||Jayasena; Sumedha (Boulder, CO), Davis; Kenneth A. (Woodside, CA), Gold; Larry (Boulder, CO)|
|Assignee:||NeXstar Pharmaceuticals, Inc. (Boulder, CO)|
|Filing Date:||Feb 14, 1997|
|Claims:||1. A purified and isolated non-naturally occurring nucleic acid ligand to CD4, wherein said ligand is an RNA selected from the group consisting of the sequences set forth in Table 2 (SEQ ID NOS:7-24).|
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