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Details for Patent: 5,869,467

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Details for Patent: 5,869,467

Title: 9-(2-phosphonylmethoxyethyl) guanine
Abstract:This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyolic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.
Inventor(s): Holy; Antonin (Horni Pocernice, CS), Rosenberg; Ivan (Prague, CS), De Clercq; Erik D. A. (Louvain, BE)
Assignee: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic (CZ) N/A (BE) Rega Stichting v.z.w. (N/A)
Filing Date:Mar 28, 1995
Application Number:08/412,398
Claims:1. A N-phosphonylmethoxyalkyl compound of formula I ##STR3## wherein R is a hydrogen atom and B is guanin-9-yl, and the water soluble salts thereof.

2. A therapeutic composition comprising a pharmaceutically acceptable carrier and an antivirally effective amount of a compound of claim 1.
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