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Details for Patent: 5,863,934

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Details for Patent: 5,863,934

Title: Use of lofexidine in the treatment of behavioral disorders
Abstract:Disclosed is a method of treating disorders which have prominent symptoms of behavioral disinhibition (e.g., Attention-Deficit Hyperactivity Disorder, Conduct Disorder, Oppositional Defiant Disorder, Tourette's Syndrome, Lesch-Nyhan Syndrome, or the disinhibitory symptoms accompanying Post-traumatic Stress Disorder or dementia) in a primate with minimal sedative side effects by administering thereto a therapeutically effective amount of lofexidine.
Inventor(s): Arnsten; Amy F. T. (Bethany, CT), Goldman-Rakic; Patricia S. (New Haven, CT), Hunt; Robert D. (Nashville, TN)
Assignee: Arnsten; Amy F. T. (Bethany, CT) Goldman-Rakic; Patricia S. (New Haven, CT) Hunt; Robert H. (Nashville, TN)
Filing Date:Oct 17, 1996
Application Number:08/734,464
Claims:1. A method of treating a behavioral disinhibition in a primate without inducing excessive sedation, comprising:

administering to the primate a behavior inhibiting, non-excessive sedation inducing dose of lofexidine.

2. The method of claim 1, comprising the additional step of readministering the dose at an interval required to obtain a desired level and duration of behavioral inhibition.

3. The method of claim 1, wherein the primate is a human.

4. The method of claim 1, wherein the behavioral disinhibition is one of Attention-Deficit Hyperactivity Disorder, Conduct Disorder, Oppositional-Defiant Disorder, Tourette's Syndrome, Lesch-Nyhan Syndrome, Post-Traumatic Stress Disorder and dementia.

5. A method of inhibiting a disinhibitory behavior in a primate without inducing excessive sedation, said method comprising administering to the primate a behavior inhibiting, non-excessive sedation inducing dose of lofexidine.

6. The method of claim 5, comprising the additional step of readministering the dose at an interval required to obtain a desired level and duration of behavioral inhibition.

7. The method of claim 5, wherein the primate is a human.

8. The method of claim 5, wherein the behavior is one of hyperactivity, agitation, impulsivity, aggression, inattention, distractibility, disorganization, uncontrolled movements, and self-mutilation.

9. The method of claim 1 or claim 5, wherein the dose of lofexidine ranges between 0.001 and 0.05 mg/kg of body weight.

10. A method of treating prefrontal cortical cognitive dysfunction in a schizophrenic patient, said method comprising administering to said patient a cognitive dysfunction-improving, non-excessive sedation inducing amount of lofexidine.
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