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Generated: December 12, 2017

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Title: Antiviral 1,3-dioxolane nucleoside analogues
Abstract:This invention includes the compounds 2'-deoxy-5-fluoro-3'-oxacytidine, (-)-2'-deoxy-5-fluoro-3'-oxacytidine, and (+)-2'-deoxy-5-fluoro-3+-oxacytidine, and pharmaceutically acceptable salts thereof for use in medical therapy, for example for the treatment or prophylaxis of an HIV infection.
Inventor(s): Liotta; Dennis C. (McDonough, GA), Schinazi; Raymond F. (Decatur, GA), Choi; Woo-Baeg (North Brunswick, NJ)
Assignee: Emory University (Atlanta, GA)
Filing Date:Nov 09, 1993
Application Number:08/150,012
Claims:1. (.+-.)-2'-Deoxy-5-fluoro-3'-oxacytidine.

2. (-)-.beta.-2'-Deoxy-5-fluoro-3'-oxacytidine as a resolved enantiomer.

3. (+)-.beta.-2'-Deoxy-5-fluoro-3'-oxacytidine as a resolved enantiomer.

4. A pharmaceutical composition that comprises 2'-deoxy-5-fluoro-3'-oxacytidine, its (-) or (+) enantiomer or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier.

5. A method for the treatment of HIV infection in human cells, comprising administering an HIV-effective amount of .beta.-2'-deoxy-5-fluoro-3'-oxacytidine or its pharmaceutically acceptable salt, optionally in a pharmaceutically acceptable carrier.

6. A method for the treatment of HIV infection in human cells, comprising administering an HIV-effective amount of (+)-.beta.-2'-deoxy-5-fluoro-3'-oxacytidine as a resolved enantiomer or its pharmaceutically acceptable salt, optionally in a pharmaceutically acceptable carrier.

7. A method for the treatment of HIV infection in human cells, comprising administering an HIV-effective amount of (-)-.beta.-2'-deoxy-5-fluoro-3'-oxacytidine as a resolved enantiomer or its pharmaceutically acceptable salt, optionally in a pharmaceutically acceptable carrier.
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