|Title:|| Platelet aggregation inhibitors|
|Abstract:||Peptides useful in inhibiting platelet aggregation are disclosed. These peptides contain the binding sequence Har-G-D and are disulfide-bridged cyclic compounds.|
|Inventor(s):|| Scarborough; Robert M. (Belmont, CA) |
|Assignee:|| COR Therapeutics, Inc. (South San Francisco, CA) |
|Filing Date:||Jun 05, 1995|
|Claims:||1. A method to detect the presence or absence of the peptide selected from the group consisting of: |
which method comprises contacting a sample suspected of containing said peptide with an antibody specifically immunoreactive with said peptide under conditions wherein a complex is formed in the presence of said peptide, and detecting the presence or absence of said complex.
2. The method of claim 1, wherein said peptide is a cyclic peptide comprising a bond between (1) a terminal Mpr and a terminal Cys or (2) a terminal Mpr and a terminal Pen.
3. The method of claim 1, wherein said peptide is selected from the group consisting of: