Details for Patent: 5,849,580
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Title: | Nucleic acid encoding a NF-.kappa.B activation regulatory protein, I.kappa.B.beta. |
Abstract: | The present invention provides a novel polypeptide, I.kappa.B-.beta., which binds to and affects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-.beta. and methods of identifying compositions which affect I.kappa.B-.beta./NF-.kappa.B complexes. Methods of treatment of disorders associated with NF-.kappa.B induced gene activation are also described herein. |
Inventor(s): | Ghosh; Sankar (Madison, CT) |
Assignee: | Yale University (New Haven, CT) |
Filing Date: | Nov 13, 1996 |
Application Number: | 08/748,428 |
Claims: | 1. An isolated nucleic acid sequence which encodes the amino acid sequence set forth as SEQ ID NO:2. 2. The nucleic acid sequence of claim wherein the nucleic acid sequence comprises the sequence set forth as SEQ ID NO:1. 3. An isolated nucleic acid sequence, wherein the nucleic acid sequence is selected from the group consisting of: (a) the nucleic acid sequence set forth as SEQ ID NO:1; (b) the nucleic acid sequence set forth as SEQ ID NO:1, which nucleic acid sequence is an RNA sequence; and (c) the nucleic acid sequence that is the full length complement of the nucleic acid sequence set forth as SEQ ID NO:1. 4. A recombinant expression vector containing the nucleic acid sequence of claim 1. 5. A host cell containing the recombinant expression vector of claim 4. 6. The vector of claim 4, wherein the vector is a virus. 7. The vector of claim 6, wherein the virus is an RNA virus. 8. The vector of claim 7, wherein the RNA virus is a retrovirus. 9. The vector of claim 4, wherein the vector is a plasmid. |