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Details for Patent: 5,849,580

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Details for Patent: 5,849,580

Title: Nucleic acid encoding a NF-.kappa.B activation regulatory protein, I.kappa.B.beta.
Abstract:The present invention provides a novel polypeptide, I.kappa.B-.beta., which binds to and affects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-.beta. and methods of identifying compositions which affect I.kappa.B-.beta./NF-.kappa.B complexes. Methods of treatment of disorders associated with NF-.kappa.B induced gene activation are also described herein.
Inventor(s): Ghosh; Sankar (Madison, CT)
Assignee: Yale University (New Haven, CT)
Filing Date:Nov 13, 1996
Application Number:08/748,428
Claims:1. An isolated nucleic acid sequence which encodes the amino acid sequence set forth as SEQ ID NO:2.

2. The nucleic acid sequence of claim wherein the nucleic acid sequence comprises the sequence set forth as SEQ ID NO:1.

3. An isolated nucleic acid sequence, wherein the nucleic acid sequence is selected from the group consisting of:

(a) the nucleic acid sequence set forth as SEQ ID NO:1;

(b) the nucleic acid sequence set forth as SEQ ID NO:1, which nucleic acid sequence is an RNA sequence; and

(c) the nucleic acid sequence that is the full length complement of the nucleic acid sequence set forth as SEQ ID NO:1.

4. A recombinant expression vector containing the nucleic acid sequence of claim 1.

5. A host cell containing the recombinant expression vector of claim 4.

6. The vector of claim 4, wherein the vector is a virus.

7. The vector of claim 6, wherein the virus is an RNA virus.

8. The vector of claim 7, wherein the RNA virus is a retrovirus.

9. The vector of claim 4, wherein the vector is a plasmid.
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