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Serving leading biopharmaceutical companies globally:

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Fish and Richardson
Queensland Health
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Generated: February 20, 2018

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Title: Quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime) pyrrolidine substituent and processes for preparing thereof
Abstract:The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically the present invention relates to a novel quinoline(naphthyridine)carboxylic acid derivative represented by the following formula (I), which has an 4-aminomethyl-3-oximepyrrolidine substituent on 7-position of the quinolone nucleus and shows a superior antibacterial activity in contrast to the known quinolone antibactrial agents having a weak activity against gram-positive bacterial strains and also has a broad antibacterial spectrum and a highly improved pharmacokinetic property ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Q are defined as described in the specification.
Inventor(s): Hong; Chang Yong (Daejeon, KR), Kim; Young Kwan (Kyungki-do, KR), Chang; Jay Hyok (Daejeon, KR), Kim; Se Ho (Seoul, KR), Choi; Hoon (Daejeon, KR), Nam; Do Hyun (Daejeon, KR), Kwak; Jin-Hwan (Daejeon, KR), Jeong; Yi Na (Daejeon, KR), Oh; Jeong In (Daejeon, KR), Kim; Mu Yong (Daejeon, KR)
Assignee: LG Chemical Ltd. (Seoul, KR)
Filing Date:Apr 04, 1997
Application Number:08/825,991
Claims:1. A compound of formula III ##STR267## or a pharmaceutically acceptable salt thereof.
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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Cantor Fitzgerald
Harvard Business School
Boehringer Ingelheim
Queensland Health

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