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Details for Patent: 5,840,891

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Details for Patent: 5,840,891

Title: 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
Abstract:The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.
Inventor(s): Nestor, Jr.; John J. (Louisville, KY), Maag; Hans (Menlo Park, CA)
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Filing Date:Mar 04, 1997
Application Number:08/812,990
Claims:1. A compound of the formula ##STR15## where P.sup.1 is a hydroxy-protecting group;

P.sup.2 is an amino-protecting group; and

the asterisk denotes an asymmetric carbon atom.

2. A compound of the formula ##STR16## where P.sup.1 is a hydroxy-protecting group removable under acidic conditions or by hydrogenolysis;

P.sup.2 is an amino-protecting group; and

the asterisk denotes an asymmetric carbon atom.

3. A compound of claim 1 where P.sup.1 is benzyl, trityl, allyl, tetrahydropyranyl, silyl, or trialkylsilyl.

4. A compound of claim 1 wherein P.sup.2 is C.sub.1-4 alkanoyl, trityl, trifluoroacetyl, N-(9-fluorenylmethoxycarbonyl), allyloxycarbonyl, N-benzyloxycarbonyl, t-butyloxycarbonyl, or phthalyl.

5. A compound of claim 3 where P.sup.2 is C.sub.1-4 alkanoyl, trityl, trifluoroacetyl, N-(9-fluorenylmethoxycarbonyl), allyloxycarbonyl, N-benzyloxycarbonyl, t-butyloxycarbonyl, or phthalyl.

6. The compound of claim 5 where P.sup.1 is benzyl and P.sup.2 is N-benzyloxycarbonyl.
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