.

BioPharmaceutical Business Intelligence

  • Analyze global market entry opportunities
  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Colorcon
Cantor Fitzgerald
Merck
Covington
AstraZeneca
Johnson and Johnson
US Army
Deloitte
Novartis
Boehringer Ingelheim

Generated: September 20, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title: Urinary follicle stimulating hormone
Abstract:Purification of human FSH from post-menopausal urine gonadogropin using immunochromatography and reverse phase HPLC steps yelds a biologically active hormone which is free from detectable traces of LH and other urinary proteins.
Inventor(s): Arpaia; Guiseppe (Rome, IT), Serani; Serenella (Rome, IT), Sirna; Antonino (Rome, IT), Villa; Stefano (Rome, IT)
Assignee: Istituto di Ricerca Cesare Serono S.p.A. (Rome, IT)
Filing Date:Dec 29, 1995
Application Number:08/580,858
Claims:1. A process for preparing a substantially pure biologically active follicle stimulating hormone (FSH) preparation, free from traces of luteinizing hormone detectable at 1.5 mIU/ml, based on the 2nd IRP-HMG reference standard for luteinizing hormone, and substantially free from all other urinary proteins, comprising subjecting a post-menopausal urinary concentrate to immunopurification using FSH-specific immobilized monoclonal antibodies to form an immunocomplex of FSH and the antibodies thereto, eluting to recover the FSH, and removing any residual traces of contaminants by reverse phase HPLC.

2. The process of claim 1 wherein the post-menopausal urinary concentrate contains Human Menopausal Gonadotropin.

3. The process of claim 1 wherein elution of FSH from the immunocomplex is carried out using as eluent an aqueous solution having a pH higher than about 10 and a molarity higher than about 0.5.

4. The process of claim 3 wherein the eluent has a pH comprised within the range of 11.3 to 11.7 and a molarity of about 1.

5. The process of claim 4 wherein the eluent is 1M ammonia.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Chubb
Johnson and Johnson
Cerilliant
Chinese Patent Office
Argus Health
Covington
Daiichi Sankyo
UBS
McKesson
Merck

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot