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|Title:||Proteinoid carriers and methods for preparation and use thereof|
|Abstract:||Improved proteinoid carriers and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The proteinoid carriers are soluble within selected pH ranges within the gastrointestinal tract and display enhanced stability towards at least one of photolysis or decomposition over time. The proteinoid carriers are prepared from proteinoids having between 2 and 20 amino acids and having a molecular weight of between about 250 and 2400 daltons.|
|Inventor(s):||Milstein; Sam J. (Larchmont, NY), Kantor; Martin L. (Mamaroneck, NY)|
|Assignee:||Emisphere Technologies, Inc. (Hawthorne, NY)|
|Filing Date:||Aug 30, 1996|
|Claims:||1. A composition comprising: |
(A) a cargo selected from the group consisting of a fragrance, a cosmetic agent and a dye encapsulated within,
(B) a microsphere or microcapsule carrier, said carrier comprising a proteinoid comprising
(i) at least one monomer selected from the group consisting of tyrosine and phenylalanine;
(ii) at least one monomer selected from the group consisting of glutamic acid, pyroglutamic acid, glutamine, and aspartic acid; and
(iii) optionally at least one monomer selected from the group consisting of lysine, arginine, and ornithine,
said proteinoid being soluble within a selected pH range.
2. The composition of claim 1, wherein said proteinoid is acid-soluble.
3. The composition of claim 1, wherein said proteinoid is base-soluble.
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