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Details for Patent: 5,837,873

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Details for Patent: 5,837,873

Title: Intermediates of retroviral protease inhibiting compounds
Abstract:A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
Inventor(s): Norbeck; Daniel W. (Lindenhurst, IL), Codacovi; Lynn M. (Antioch, IL), Wittenberger; Steven J. (Mundelein, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Filing Date:Mar 24, 1995
Application Number:08/410,162
Claims:1. A compound of the formula: ##STR11## wherein P.sub.1 and P.sub.2 are independently selected from hydrogen and an N-protecting group selected from the group consisting of (a) --C(O)OR.sup.a wherein R.sup.a is methyl, isopropyl, cyclopropylmethyl, 1-methyl-1-cyclopropylmethyl, diisopropylmethyl, 9-fluorenylmethyl, 9-(2-sulfo)fluorenylmethyl, 2,2,2-trichloroethyl, 2-haloethyl, 2-trimethylsilylethyl, 2-methylthioethyl, 2-methylsulfonylethyl, 2-(p-toluenesulfonyl)ethyl, 2-phosphonioethyl, 1,1-dimethylpropynyl, 1,1-dimethyl-3-(N,N-dimethylcarboxamido)propyl, 1,1-diphenyl-3-(N,N-diethylamino)propyl, 1-methyl-1-(1-adamantyl)ethyl, 1-methyl-1-phenylethyl, 1-methyl-1-(3,5-dimethoxyphenyl)ethyl, 1-methyl-1-(4-biphenylyl)ethyl, 1-methyl-1-(p-phenylazophenyl)ethyl, 1,1-dimethyl-2-haloethyl, 1,1-dimethyl-2,2,2-trichloroethyl, 1,1-dimethyl-2-cyanoethyl, Isobutyl, t-butyl, t-amyl, cyclobutyl, 1-methylcyclobutyl, cyclopentyl, cyclohexyl, 1-methyicyclohexyl, 1-adamantyl, Isobornyl, vinyl, allyl, cinnamyl, phenyl, 2,4,6-trl-t-butylphenyl, m-nitrophenyl, p-nitrophenyl, benzyl, 2,4,6-trimethylbenzyl, p-methoxybenzyl, 3,5-dimethoxybenzyl, p-decyloxybenzyl, p-nitrobenzyl, o-nitrobenzyl, 3,4-dimethoxy-6-nitrobenzyl, p-bromobenzyl, chlorobenzyl, 2,4-dichlorobenzyl, p-cyanobenzyl, o-(N,N-dimethylcarboxamido)benzyl, p-(dihydroxyboryl)benzyl, p-(phenylazo)benzyl, p-(p'-methoxyphenylazo)benzyl, 9-anthrylmethyl, diphenylmethyl or phenyl(o-nitrophenyl)methyl, (b) --C(O)SR.sup.a wherein R.sup.a is phenyl or benzyl, (c) formyl, (d) acetyl, (e) chloroacetyl, (f) trichloroacetyl, (g) trifluoroacetyl, (h) o-nitrophenylacetyl, (i) o-nitrophenoxyacetyl, (j) acetoacetyl, (k) t-butylacetyl, (l) (N'-dithiobenzyloxycarbonylamino)acetyl, (m) 3-phenylpropionyl, (n) 3-(D-hydroxyphenyl)propionyl, (o) 3-(o-nitrophenoxy)propionyl, (p) 2-methyl-2-(o-nitrophenoxy)propionyl, (q) 2-methyl-2-(o-phenylazophenoxy)propionyl, (r) 4-chlorobutyryl, (s) Isobutyryl, (t) isovaleryl, (u) o-nitrocinnamoyl, (v) benzoyl, (w) p-phenylbenzoyl, (x) p-methoxybenzoyl, (y) o-nitrobenzoyl, (z) o-(benzoyloxymethyl)benzoyl, (aa) phthaloyl, (bb) 2,3-diphenylmaleoyl, (cc) dithiasuccinoyl, (dd) allyl, (ee) phenacyl, (ff) 3-acetoxypropyl, (gg) benzyl, (hh) 3,4-dimethoxybenzyl, (ii) o-nitrobenzyl, (jj) di-(p-methoxyphenyl)methyl, (kk) triphenylmethyl, (ll) (p-methoxyphenyl)diphenylmethyl, (mm) dibenzosuberyl, (nn) N',N'-dimethylaminomethylene, (oo) isopropylidene, (pp) benzylidene, (qq) p-methoxybenzylidene, (rr) p-nitrobenzylidene, (ss) salicylidene, (tt) 5-chlorosalicylidene. (uu) diphenylmethylene, (vv) (5-chloro-2-hydroxyphenyl)phenylmethylene, (ww) trimethylsilyl, (xx) benzenesulfonyl, (yy) p-methoxybenzenesulfonyl, (zz) 2,4,6-trimethylbenzenesulfonyl, (aaa) toluenesulfonyl, (bbb) benzylsulfonyl, (ccc) p-methylbenzylsulfonyl, (ddd) trifluoromethylsulfonyl and (eee) phenacylsulfonyl; R.sub.1 ' is hydrogen, C.sub.1 -to-C.sub.6 -loweralkyl, C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl or an O-protecting group selected from the group consisting of methoxymethyl, methylthiomethyl, benzyloxymethyl, t-butoxymethyl, 2-methoxyethoxymethyl, 2,2,2-trichloroethoxymethyl, bis-(2-chloroethoxy)methyl, 2-(trimethylsilyl)ethoxymethyl, tetrahydropyranyl, 3-bromotetrahydropyranyl, tetrahydrothiopyranyl, 4-methoxytetrahydropyranyl, 4-methoxytetrahydrothiopyranyl, 4-methoxytetrahydrothiopyranyi-S,S-dioxo, tetrahydrofuranyl, tetrahydrothiofuranyl, 1-ethoxyethyl, 1-methyl-1-methoxyethyl, 1-(isopropoxy)ethyl, 2,2,2-trichloroethyl, 2-(phenylselenyl)ethyl, t-butyl, allyl, cinnamyl, p-chlorophenyl, benzyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, p-halobenzyl, p-cyanobenzyl, diphenylmethyl, 5-dibenzosuberyl, triphenylmethyl, .alpha.-naphthyidiphenylmethyl, p-methoxyphenyidiphenylmethyl, p-(p'-bromophenacyloxy)phenyidiphenylmethyl, 9-anthryl, 9-(9-phenyl)xanthenyl, 9-(9-phenyl-10-oxo)anthryl, trimethylsilyi, triethylsilyi, isopropyidimethylsilyl, t-butyidimethylsilyi, (triphenylmethyl)dimethylsilyi, t-butyidiphenylsilyl, methyidiisopropylsilyl, methyl-di-t-butylsilyl, tribenzylsilyl, tri-p-xylylsilyl, triisopropylsilyl, triphenylsilyl, formyl, benzoylformyle, acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, trifluoroacetyl, methoxyacetyl, triphenylmethoxyacetyl, phenoxyacetyl, p-chlorophenoxyacetyl, 2,6-dichloro-4-methylphenoxyacetyl, 2,6-dichloro-4-(1,1,3,3-tetramethylbutyl)phenoxyacetyl, 2,4-bis(1,1-dimethylpropyl)phenoxyacetyl, chlorodiphenylacetyl, 3-phenylproplonyl, 3-benzoylproplonyl, isobutyryl, monosuccinyl, 4-oxopentanoyl, pivaloyl, adamantoyl, crotonyl, 4-methoxycrotonyl, (E)-2-methyl-2-butenoyl, benzoyl, o-(dibromomethyl)benzoyl, o-(methoxycarbonyi)benzoyl, p-phenylbenzoyl, 2,4,6-trimethylbenzoyl and .alpha.-naphthoyl; and R.sub.2 and R.sub.3 are independently selected from (a) aryl-C.sub.1 -to-C.sub.6 -alkyl wherein aryl is selected from phenyl, naphthyl, tetrahydronaphthyl, indanyl, indenyl and substituted phenyl, substituted naphthyl, substituted tetrahydronaphthyl, substituted indanyl and substituted indenyl wherein the substituted aryl groups are substituted with one, two or three substituents independently selected from C.sub.1 -to-C.sub.6 -loweralkyl, halo-C.sub.1 -to-C.sub.6 -alkyl, C.sub.1 -to-C.sub.6 -alkoxy, C.sub.1 -to-C.sub.6 -thioalkoxy, C.sub.1 -to-C.sub.6 -alkoxycarbonyl, C.sub.1 -to-C.sub.6 -alkanoyl, hydroxy, halo, mercapto, nitro, amino, C.sub.1 -to-C.sub.6 -alkylamino, C.sub.1 -to-C.sub.6 -alkylamino, carboxaldehyde, carboxy, carboxamide, unsubstituted aryl-C.sub.1 -to-C.sub.6 -alkyl, unsubstituted aryl-C.sub.1 -to-C.sub.6 -alkoxy, amino-C.sub.1 -to-C.sub.6 -alkyl, amino-C.sub.1 -to-C.sub.6 -alkoxy, C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkyl, C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkoxy, di-C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkyl, di-C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkoxy, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkyl, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkoxy, di-C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkyl, di(C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkoxy, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)(C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkyl, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)(C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkoxy, hydroxy-C.sub.1 -to-C.sub.6 -alkyl, hydroxy-C.sub.1 -to-C.sub.6 -alkoxy, carboxy-C.sub.1 -to-C.sub.6 -alkyl, carboxy-C.sub.1 -to-C.sub.6 -alkoxy, C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl, C.sub.1 -to-C.sub.6 -thioalkoxy-C.sub.1 -to-C.sub.6 -alkyl, poly-C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl and di-C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl and (b) C.sub.3 -to-C.sub.7 cycloalkyl-C.sub.1 -to-C.sub.6 -alkyl; or a salt thereof.

2. A compound according to claim 1 of the formula: ##STR12## wherein P.sub.1 and P.sub.2 are independently selected from hydrogen and an N-protecting group as defined therein; R.sub.1 ' is hydrogen or an O-protecting group as defined therein; and R.sub.2 and R.sub.3 are independently selected from arylalkyl as defined therein; or a salt thereof.

3. A compound of the formula: ##STR13## wherein P.sub.1 and P.sub.2 are independently selected from hydrogen and an N-protecting group selected from the group consisting of (a) --C(O)OR.sup.a wherein R.sup.a is methyl, isopropyl, cyclopropylmethyl, 1-methyl-1-cyclopropylmethyl, diisopropylmethyl, 9-fluorenylmethyl, 9-(2-sulfo)fluorenylmethyl, 2,2,2-trichloroethyl, 2-haloethyl, 2-trimethylsilylethyl, 2-methylthioethyl, 2-methylsulfonylethyl, 2-(p-toluenesulfonyl)ethyl, 2-phosphonioethyl, 1,1-dimethylpropynyl, 1,1-dimethyl-3-(N,N-dimethylcarboxamido)propyl, 1,1-diphenyl-3-(N,N-diethylamino)propyl, 1-methyl-1-(1-adamantyl)ethyl, 1-methyl-1-phenylethyl, 1-methyl-1-(3,5-dimethoxyphenyl)ethyl, 1-methyl-1-(4-biphenylyl)ethyl, 1-methyl-1-(p-phenylazophenyl)ethyl, 1,1-dimethyl-2-haloethyl, 1,1-dimethyl-2,2,2-trichloroethyl, 1,1-dimethyl-2-cyanoethyl, Isobutyl, t-butyl, t-amyl, cyclobutyl, 1-methylcyclobutyl, cyclopentyl, cyclohexyl, 1-methyicyclohexyl, 1-adamantyl, isobornyl, vinyl, allyl, cinnamyl, phenyl, 2,4,6-trl-t-butylphenyl, m-nitrophenyl, p-nitrophenyl, benzyl, 2,4,6-trimethylbenzyl, p-methoxybenzyl, 3,5-dimethoxybenzyl, p-decyloxybenzyl, p-nitrobenzyl, o-nitrobenzyl, 3,4-dimethoxy-6-nitrobenzyl, p-bromobenzyl, chlorobenzyl, 2,4-dichlorobenzyl, p-cyanobenzyl, o-(N,N-dimethylcarboxamido)benzyl, p-(dihydroxyboryl)benzyl, p-(phenylazo)benzyl, p-(p'-methoxyphenylazo)benzyl, 9-anthrylmethyl, diphenylmethyl or phenyl(o-nitrophenyl)methyl, (b) --C(O)SR.sup.a wherein R.sup.a is phenyl or benzyl, (c) formyl, (d) acetyl, (e) chloroacetyl, (f) trichloroacetyl, (g) trifluoroacetyl, (h) o-nitrophenylacetyl, (i) o-nitrophenoxyacetyl, (j) acetoacetyl, (k) t-butylacetyl, (l) (N'-dithiobenzyloxycarbonylamino)acetyl, (m) 3-phenylpropionyl, (n) 3-(D-hydroxyphenyl)propionyl, (o) 3-(o-nitrophenoxy)propionyl, (p) 2-methyl-2-(o-nitrophenoxy)propionyl, (q) 2-methyl-2-(o-phenylazophenoxy)propionyl, (r) 4-chlorobutyryl, (s) Isobutyryl, (t) isovaleryl, (u) o-nitrocinnamoyl, (v) benzoyl, (w) p-phenylbenzoyl, (x) p-methoxybenzoyl, (y) o-nitrobenzoyl, (z) o-(benzoyloxymethyl)benzoyl, (aa) phthaloyl, (bb) 2,3-diphenylmaleoyl, (cc) dithiasuccinoyl, (dd) allyl, (ee) phenacyl, (ff) 3-acetoxypropyl, (gg) benzyl, (hh) 3,4-dimethoxybenzyl, (ii) o-nitrobenzyl, (jj) di-(p-methoxyphenyl)methyl, (kk) triphenylmethyl, (ll) (p-methoxyphenyl)diphenylmethyl, (mm) dibenzosuberyl, (nn) N',N'-dimethylaminomethylene, (oo) isopropylidene, (pp) benzylidene, (qq) p-methoxybenzylidene, (rr) p-nitrobenzylidene, (ss) salicylidene, (tt) 5-chlorosalicylidene. (uu) diphenylmethylene, (vv) (5-chloro-2-hydroxyphenyl)phenylmethylene, (ww) trimethylsilyl, (xx) benzenesulfonyl, (yy) p-methoxybenzenesulfonyl, (zz) 2,4,6-trimethylbenzenesulfonyl, (aaa) toluenesulfonyl, (bbb) benzylsulfonyl, (ccc) p-methylbenzylsulfonyl, (ddd) trifluoromethylsulfonyl and (eee) phenacylsulfonyl; R.sub.1 ' is hydrogen or an O-protecting group selected from the group consisting of methoxymethyl, methylthiomethyl, benzyloxymethyl, t-butoxymethyl, 2-methoxyethoxymethyl, 2,2,2-trichloroethoxymethyl, bis-(2-chloroethoxy)methyl, 2-(trimethylsilyl)ethoxymethyl, tetrahydropyranyl, 3-bromotetrahydropyranyl, tetrahydrothiopyranyl, 4-methoxytetrahydropyranyl, 4-methoxytetrahydrothiopyranyl, 4-methoxytetrahydrothiopyranyi-S,S-dioxo, tetrahydrofuranyl, tetrahydrothiofuranyl, 1-ethoxyethyl, 1-methyl-1-methoxyethyl, 1-(isopropoxy)ethyl, 2,2,2-trichloroethyl, 2-(phenylselenyl)ethyl, t-butyl, allyl, cinnamyl, p-chlorophenyl, benzyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, p-halobenzyl, p-cyanobenzyl, diphenylmethyl, 5-dibenzosuberyl, triphenylmethyl, .alpha.-naphthyidiphenylmethyl, p-methoxyphenyidiphenylmethyl, p-(p'-bromophenacyloxy)phenyidiphenylmethyl, 9-anthryl, 9-(9-phenyl)xanthenyl, 9-(9-phenyl-10-oxo)anthryl, trimethylsilyi, triethylsilyi, isopropyidimethylsilyl, t-butyidimethylsilyi, (triphenylmethyl)dimethylsilyi, t-butyidiphenylsilyl, methyidiisopropylsilyl, methyl-di-t-butylsilyl, tribenzylsilyl, tri-p-xylylsilyl, triisopropylsilyl, triphenylsilyl, formyl, benzoylformyle, acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, trifluoroacetyl, methoxyacetyl, triphenylmethoxyacetyl, phenoxyacetyl, p-chlorophenoxyacetyl, 2,6-dichloro-4-methylphenoxyacetyl, 2,6-dichloro-4-(1,1,3,3-tetramethylbutyl)phenoxyacetyl, 2,4-bis(1,1-dimethylpropyl)phenoxyacetyl, chlorodiphenylacetyl, 3-phenylproplonyl, 3-benzoylproplonyl, isobutyryl, monosuccinyl, 4-oxopentanoyl, pivaloyl, adamantoyl, crotonyl, 4-methoxycrotonyl, (E)-2-methyl-2-butenoyl, benzoyl, o-(dibromomethyl)benzoyl, o-(methoxycarbonyi)benzoyl, p-phenylbenzoyl, 2,4,6-trimethylbenzoyl and .alpha.-naphthoyl; and R.sub.2 and R.sub.3 are independently selected from (a) aryl-C.sub.1 -to-C.sub.6 -alkyl wherein aryl is selected from phenyl, naphthyl, tetrahydronaphthyl, indanyl, indenyl and substituted phenyl, substituted naphthyl, substituted tetrahydronaphthyl, substituted indanyl and substituted indenyl wherein the substituted aryl groups are substituted with one, two or three substituents independently selected from C.sub.1 -to-C.sub.6 -loweralkyl, halo-C.sub.1 -to-C.sub.6 -alkyl, C.sub.1 -to-C.sub.6 -alkoxy, C.sub.1 -to-C.sub.6 -thioalkoxy, C.sub.1 -to-C.sub.6 -alkoxycarbonyl, C.sub.1 -to-C.sub.6 -alkanoyl, hydroxy, halo, mercapto, nitro, amino, C.sub.1 -to-C.sub.6 -alkylamino, C.sub.1 -to-C.sub.6 -alkylamino, carboxaldehyde, carboxy, carboxamide, unsubstituted aryl-C.sub.1 -to-C.sub.6 -alkyl, unsubstituted aryl-C.sub.1 -to-C.sub.6 -alkoxy, amino-C.sub.1 -to-C.sub.6 -alkyl, amino-C.sub.1 -to-C.sub.6 -alkoxy, C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkyl, C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkoxy, di-C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkyl, di-C.sub.1 -to-C.sub.6 -alkylamino-C.sub.1 -to-C.sub.6 -alkoxy, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkyl, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkoxy, di-C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkyl, di(C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkoxy, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)(C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkyl, (C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl)(C.sub.1 -to-C.sub.6 -alkyl)amino-C.sub.1 -to-C.sub.6 -alkoxy, hydroxy-C.sub.1 -to-C.sub.6 -alkyl, hydroxy-C.sub.1 -to-C.sub.6 -alkoxy, carboxy-C.sub.1 -to-C.sub.6 -alkyl, carboxy-C.sub.1 -to-C.sub.6 -alkoxy, C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl, C.sub.1 -to-C.sub.6 -thioalkoxy-C.sub.1 -to-C.sub.6 -alkyl, poly-C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl and di-C.sub.1 -to-C.sub.6 -alkoxy-C.sub.1 -to-C.sub.6 -alkyl; or a salt thereof; wherein the carbon atom bearing the R.sub.2 substituent has the "S" configuration, the carbon atom bearing the OR.sub.1, substituent has the "S" configuration and the carbon atom bearing the R.sub.3 substituent has the "S" configuration.

4. A compound according to claim 3 of the formula: ##STR14## wherein P.sub.1 and P.sub.2 are independently selected from hydrogen and an N-protecting group as defined therein; R.sub.1 ' is hydrogen or an O-protecting group as defined therein; and R.sub.2 and R.sub.3 are benzyl; or a salt or ester thereof; wherein the carbon atom bearing the R.sub.2 substituent has the "S" configuration, the carbon atom bearing the OR.sub.1, substituent has the "S" configuration and the carbon atom bearing the R.sub.3 substituent has the "S" configuration.

5. A compound selected from the group consisting of:

(2S,3S,5S)-2,5-Diamino-1,6-diphenyl-3-hydroxyhexane;

(2S,3S,5S)-3-Acetoxy-2,5-bis-(N-Cbz-amino)-1,6-diphenylhexane;

(2S,3S,5S)-2,5-Bis-(N-Cbz-amino)-1,6-diphenyl-3-hydroxyhexane;

(2S,3S,5S)-2,5-Bis-(N-Boc-amino)-1,6-diphenyl-3-hydroxyhexane;

(2S,3S,5S)-2,5-Bis-(N-(t-butylacetyl)-amino)-1,6-diphenyl-3-hydroxyhexane;

(2S,3S,5S)-2,5-Diamino-1,6-di-(4-hydroxyphenyl)-3-hydroxyhexane;

(2S,3S,5S)-5-Amino-2-(N-(((t-butyl)oxy)-carbonyl)amino)-1,6-diphenyl-3-hydr oxyhexane;

(2S,3S,5S)-2-Amino-5-(N-(((t-butyl)oxy)carbonyl)amino)-1,6-diphenyl-3-hydro xyhexane;

(2S,3S,5S)-2,5-Bis-(N-(benzylidene)amino)-1,6-diphenyl-3-hydroxyhexane;

2(S),5(S)-Bis-(N-(p-nitrophenoxycarbonyl)-amino)-1,6-diphenyl-3(S)-trimethy lsiloxy-hexane;

(2S,3S,5S)-2,5-Di-(Boc-amino)-1,6-diphenyl-3-hydroxy-hexane;

(2S,3S,5S)-1,6-Diphenyl-2,5-di-(phenyloxycarbonylamino)-3-hydroxy-hexane;

(2S,3S,5S)-2,5-Di-(isopropyloxycarbonylamino)-1,6-diphenyl-3-hydroxy-hexane

(2S,3S,5S)-2,5-Di-(isovalerylamino)-1,6-diphenyl-3-hydroxy-hexane;

(2S,3S,5S)-2,5-Di-(isobutyloxycarbonylamino)-1,6-diphenyl-3-hydroxy-hexane;

(2S,3R,5S)-1,6-Diphenyl-3-hydroxy-2,5-di-(Boc-amino)-hexane;

or a salt thereof.

6. The compound (2S,3S,5S)-2,5-Diamino-1,6-diphenyl-3-hydroxyhexane; or a salt thereof.

7. The compound (2S,3S,5S)-5-Amino-2-(N-(((t-butyl)oxy)-carbonyl)amino)-1,6-diphenyl-3-hyd roxyhexane; or a salt thereof.

8. The compound (2S,3S,5S)-2-Amino-5-(N-(((t-butyl)oxy)carbonyl)amino)-1,6-diphenyl-3-hydr oxyhexane; or a salt thereof.
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