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Details for Patent: 5,827,834

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Details for Patent: 5,827,834

Title: Method of using hyaluronic acid or its pharmaceutically acceptable salts for the treatment of disease
Abstract:A method of treating anorectal disease is provided which comprises applying to anorectal tissue in need of such treatment an effective amount of a composition comprising a pharmaceutically acceptable carrier and hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount8 of up to about 10% by weight.
Inventor(s): Falk; Rudolf Edgar (Toronto, CA), Asculai; Samuel S. (Toronto, CA)
Assignee: Hyal Pharmaceutical Corporation (Mississauga, CA)
Filing Date:Aug 05, 1994
Application Number:08/286,263
Claims:1. A method of transporting a non-steroidal anti-inflammatory drug (NSAID), and hyaluronic acid or a pharmaceutically acceptable salt thereof, to a site in a patient suffering from a disease, wherein said site is in need of treatment with the NSAID, comprising topically administering an amount of the NSAID effective for treating the site, and an amount of hyaluronic acid or a pharmaceutically acceptable salt thereof in excess of 200 mg, wherein the hyaluronic acid or pharmaceutically acceptable salt thereof has a molecular weight less than 750,000 daltons but greater than 150,000 daltons.

2. A method of decreasing side effects which would be expected to arise from administration of a non-steroidal anti-inflammatory drug (NSAID) to a patient suffering from a disease and in need of said administration, wherein said side effects are selected from the group consisting of gastro-intestinal distress, neurological abnormalities, and depression, comprising topically administering to the patient an amount of the NSAID effective for treating the disease, and an amount of hyaluronic acid or a pharmaceutically acceptable salt thereof in excess of 200 mg, wherein the hyaluronic acid or pharmaceutically acceptable salt thereof has a molecular weight less than 750,000 daltons but greater than 150,000 daltons.

3. A method of treating anorectal disease comprising topically administering to anorectal tissue in need of such treatment a composition comprising a therapeutically effective amount of a drug useful for treating anorectal disease, and an amount of hyaluronic acid or a pharmaceutically acceptable salt thereof, wherein the hyaluronic acid or pharmaceutically acceptable salt thereof constitutes 2% by weight of the composition, and has a molecular weight less than 750,000 daltons but greater than 150,000 daltons.

4. The method of claim 3 wherein the drug useful for treating anorectal disease is an anti-inflammatory drug.

5. The method of claim 4 wherein the anti-inflammatory drug is a non-steroidal anti-inflammatory drug (NSAID).

6. The method of claim 3 wherein the anorectal disease is selected from the group consisting of a tumor and chronic infection.
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