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Details for Patent: 5,817,642

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Details for Patent: 5,817,642

Title: Clearing of atherosclerosis
Abstract:A method of clearing atherosclerosis comprising the step of administering to a patient, at least one dosage amount of a pharmaceutical composition comprising an effective non-toxic amount of each of a chelating agent, a non-steroidal anti-inflammatory drug (NSAID), an anti-oxidant and a form of hyaluronic acid, selected from hyaluronic acid, salts thereof, homologues, analogues, derivatives, esters, complexes, fragments and subunits.
Inventor(s): Falk; Rudolf Edgar (Toronto, CA), Asculai; Samuel Simon (Toronto, CA)
Assignee: Hyal Pharmaceutical Corporation (Mississauga, CA)
Filing Date:Aug 15, 1995
Application Number:08/464,769
Claims:1. A method of clearing atherosclerosis comprising the step of administering to a patient, at least one dosage amount of a pharmaceutical composition comprising an effective non-toxic amount of each of a chelating agent, a non-steroidal anti-inflammatory drug (NSAID), an anti-oxidant and a form of hyaluronic acid, selected from the group consisting of hyaluronic acid and its non-toxic salts.

2. The method of claim 1 wherein the form of hyaluronic acid is sodium hyaluronate having a molecular weight less than about 750,000 daltons.

3. The method of claim 2 wherein the at least one dosage amount comprising a plurality of dosage amounts administered intravenously at suitable intervals over a period of time.

4. The method of claim 3 wherein the chelating agent is EDTA.

5. The method of claim 3 wherein the NSAID is selected from the group consisting of diclofenac, tromethamine salt of ketoralac, indomethacin, piroxicam, and ibuprofen.

6. The method of claim 3 wherein the anti-oxidant is Vitamin C.

7. The method of claim 2 wherein the at least one such dosage amount comprises

(i) about 1-3 gm of the chelating agent/70 kg person;

(ii) about 15-30 mg of an NSAID;

(iii) about 12-50 gm anti-oxidant; and

(iv) between about 50 mg to well in excess of 1000 mg of the form of hyaluronic acid;

in sterile water.

8. The method of claim 3 wherein the at least one such dosage amount comprises

(i) about 1-3 gm of the chelating agent/70 kg person;

(ii) about 15-30 mg of an NSAID;

(iii) about 12-50 gm anti-oxidant; and

(iv) between about 50 mg to well in excess of 1000 mg of the form of hyaluronic acid;

in sterile water.

9. The method of claim 7 or 8 wherein the chelating agent is EDTA.

10. The method of claim 7 or 8 wherein the NSAID is selected from the group consisting of diclofenac sodium and tromethamine salt of ketoralac.

11. The method of claim 7 or 8 wherein the anti-oxidant is selected from 12.5 to 25 gm of Vitamin C.

12. The method of claim 7 or 8 wherein the amount of sodium hyaluronate exceeds 200 mg.

13. The method of claim 7 or 8 wherein the amount of sodium hyaluronate is about 100 to about 120 mg, and the sodium hyaluronate has a molecular weight of about 150,000-225,000 daltons.

14. The method of claim 7 or 8 wherein the dosage amount further comprises 200 ml of sterile water.

15. The method of claim 7 or 8 wherein the dosage amount further comprises an effective amount of a local anesthetic.

16. The method of claim 15 wherein the dosage amount further comprises an effective amount of bicarbonate of soda.
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