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|Title:||Intermediates for anti-microbial quinolone carboxylic acids|
|Abstract:||Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.|
|Inventor(s):||Ueda; Hiraki (Michima, JP), Miyamoto; Hisashi (Tokushima, JP), Yamashita; Hiroshi (Tokushima, JP), Tone; Hitoshi (Itano, JP)|
|Assignee:||Otsuka Pharmaceutical Company, Limited (Tokyo, JP)|
|Filing Date:||Sep 03, 1997|
|Claims:||1. A compound of the formula: ##STR36## wherein R.sup.32 is a lower alkyl group; D is a carboxyl group; X.sup.2 is a halogen atom; X.sup.3 is a halogen atom; and X.sup.4 is a halogen atom. |
2. A compound according to claim 1, wherein the compound is of the following formula: ##STR37## wherein X.sup.2, X.sup.3, X.sup.4, and R.sup.32 are as defined in claim 1.
3. A compound according to claim 1, which is a member selected from the group consisting of
2-methyl-3-fluoro-4,6-dibromobenzoic acid; and
4. A compound according to claim 1, which is 2-methyl-3-fluoro-4,6-dibromobenzoic acid.