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|Abstract:||Disclosed is a method and patch for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection.|
|Inventor(s):||Lipton; Stuart A. (Newton, MA)|
|Assignee:||The Children's Medical Center Corporation (Boston, MA)|
|Filing Date:||Jun 07, 1995|
|Claims:||1. A transdermal patch suitable for delivering nitroglycerin to a human patient, said patch: |
a) having a surface area exceeding 50 cm.sup.2 ;
b) being loaded with nitroglycerin to deliver at least 3.0 mg/hr;
c) being loaded to release nitroglycerin continually for a period exceeding 12 hours.
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