.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,801,164

« Back to Dashboard

Details for Patent: 5,801,164

Title: Methods of treating osteoporosis prophylactically or therapeutically
Abstract:Methods of treating osteoporosis prophylactically or therapeutically are disclosed. The method of treating osteoporosis includes administering to a patient suffering therefrom an effective amount to treat the osteoporosis of novel 1.alpha.-hydroxyvitamin D.sub.4 and novel analogues 1,25-dihydroxyvitamin D.sub.4 and 1,24-dihydroxyvitamin D.sub.4, the aforementioned compounds having lower toxicity as measured by an LD.sub.50 test in rats when compared to a corresponding vitamin D.sub.3 compound. The method of administering the compound is substantially without occurrence of hypercalcemia.
Inventor(s): Knutson; Joyce C. (Madison, WI), Bishop; Charles W. (Verona, WI), Moriarty; Robert M. (Oak Park, IL)
Assignee: Bone Care International, Inc. (Madison, WI)
Filing Date:Jun 07, 1995
Application Number:08/480,310
Claims:1. A method of treating osteoporosis, comprising administering to a patient suffering therefrom an amount effective to treat the osteoporosis of a compound of the formula (I) ##STR2## wherein R.sub.1 is either H or OH and R.sub.2 is either H or OH.

2. A method of treating osteoporosis, comprising administering to a patient suffering therefrom an effective amount of 1.alpha.,24-dihydroxyvitamin D.sub.4.

3. The method of claim 1 wherein said compound of formula (I) is 1.alpha.-hydroxyvitamin D.sub.4.

4. The method of claim 1, wherein said amount of the compound of formula (I) is administered in a daily dosage of about 0.04 .mu.g/kg to about 0.3 .mu.g/kg.

5. The method of claim 1, further comprising a therapeutic agent selected from the group consisting of estrogen, bisphosphonate and combinations thereof.

6. The method of claim 1, further comprising continuing said administering step until bone mass increases and the patient's calcium balance becomes positive, thereby indicating mineral accumulation in the patient's skeleton.

7. The method of claim 2, wherein said amount is at least 3 .mu.g/day.

8. The method of claim 2, wherein said administering of said amount of 1.alpha.,24-dihydroxyvitamin D.sub.4 is substantially without the occurrence of hypercalcemia, said amount being at least 2.5 .mu.g/day.

9. The method of claim 2, further comprising administering a therapeutic agent selected from the group consisting of estrogen, bisphosphonate and combinations thereof.

10. The method of claim 2, further comprising continuing said administering step until bone mass increase and the patient's calcium balance become positive, thereby indicating mineral accumulation in the patient's skeleton.

11. The method of claim 2 wherein said administering step comprises orally administering 1.alpha.,24-dihydroxyvitamin D.sub.4.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc