Details for Patent: 5,795,868
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Title: | Platelet aggregation inhibitors |
Abstract: | Peptides useful in inhibiting platelet aggregation are disclosed. These peptides contain the binding sequence Har-G-D and are disulfide-bridged cyclic compounds. |
Inventor(s): | Scarborough; Robert M. (Belmont, CA) |
Assignee: | COR Therapeutics, Inc. (South San Francisco, CA) |
Filing Date: | Jun 05, 1995 |
Application Number: | 08/462,660 |
Claims: | 1. A peptide selected from the group consisting of: 2. The peptide of claim 1, wherein said peptide is a cyclic peptide comprising a bond between ( 1) a terminal Mpr and a terminal Cys or (2) a terminal Mpr and a terminal Pen. 3. The peptide of claim 1, wherein said peptide is ##STR3## 4. The peptide of claim 1, wherein said peptide is ##STR4## 5. The peptide of claim 1, wherein said peptide is ##STR5## 6. The peptide of claim 1, wherein said peptide is ##STR6## 7. The peptide of claim 1, wherein said peptide is ##STR7## 8. The peptide of claim 1, wherein said peptide is ##STR8## 9. The peptide of claim 1, wherein said peptide is ##STR9## 10. The peptide of claim 1, wherein said peptide is ##STR10## 11. The peptide of claim 1, wherein said peptide is ##STR11## 12. The peptide of claim 1, wherein said peptide is ##STR12## 13. The peptide of claim 1, wherein said peptide is ##STR13## 14. The peptide of claim 1, wherein said peptide is ##STR14## 15. The peptide of claim 1, wherein said peptide is ##STR15## 16. The peptide of claim 1, wherein said peptide is ##STR16## 17. The peptide of claim 1, wherein said peptide is ##STR17## 18. The peptide of claim 1, wherein said peptide is ##STR18## 19. The peptide of claim 1, wherein said peptide is ##STR19## 20. The peptide of claim 1, wherein said peptide is ##STR20## 21. The peptide of claim 1, wherein said peptide is ##STR21## 22. The peptide of claim 1, wherein said peptide is ##STR22## 23. The peptide of claim 1, wherein said peptide is ##STR23## |