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Details for Patent: 5,792,451

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Details for Patent: 5,792,451

Title: Oral drug delivery compositions and methods
Abstract:The present invention relates to an oral drug delivery system, and in particular to modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acid derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. These mixtures are suitable for oral administration of biologically active agents to mammals. Methods for the preparation of such amino acids are also disclosed.
Inventor(s): Sarubbi; Donald J. (Bronxville, NY), Leone-Bay; Andrea (Ridgefield, CT), Paton; Duncan R. (Purdys, NY)
Assignee: Emisphere Technologies, Inc. (Hawthorne, NY)
Filing Date:Mar 02, 1994
Application Number:08/205,511
Claims:1. An oral delivery pharmacological composition comprising:

(A) at least one biologically-active agent; and

(B) at least one carrier comprising

(a) (i) at least one acylated aldehyde of an amino acid,

(ii) at least one acylated ketone of an amino acid,

(iii) at least one acylated aldehyde of a peptide,

(iv) at least one acylated ketone of a peptide, or

(v) any combination of (a)(i), (a)(ii), (a)(iii) and (a)(iv);

(b) (i) carboxymethyl-phenylalanine-leucine,

(ii) 2-carboxy-3-phenylpropionyl-leucine,

(iii) 2-benzylsuccinic acid,

(iv) (phenylsulfonamide) phenylbutyric acid,

(v) or any combination of (b)(i), (b)(ii), (b)(iii) and (b)(iv); or

(c) a combination of (a) and (b);

wherein said carrier is in an amount effective for oral delivery of said biologically-active agent.

2. The composition according to claim 1, wherein said biologically-active agent comprises at least one peptide, mucopolysaccharide, carbohydrate, or lipid.

3. The composition according to claim 2, wherein said biologically-active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, vancomycin, desferrioxamine (DFO), and any combination thereof.

4. The composition according to claim 2, wherein said biologically-active agent comprises an interferon, interleukin-II, insulin, heparin, calcitonin, oxytocin, vasopressin, vancomycin, desferrioxamine (DFO) and combinations thereof.

5. The composition according to claim 4, wherein said biologically-active agent comprises calcitonin.

6. The composition according to claim 1, wherein said amino acid is a naturally occurring amino acid.

7. The composition according to claim 1, wherein said amino acid is a synthetic amino acid.

8. The composition according to claim 1, wherein said amino acid is an .alpha.-amino acid.

9. The composition according to claim 1, wherein said amino acid is selected from the group consisting of alanine, arginine, asparagine, aspartic acid, citrulline, cysteine, cystine, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, phenylglycine, proline, serine, threonine, tryptophan tyrosine, valine, hydroxy proline, .gamma.-carboxyglutamate, O-phosphoserine, .beta.-alanine, .alpha.-amino butyric acid, .gamma.-amino butyric acid, .alpha.-amino isobutyric acid, .epsilon.-amino caproic acid, 7-amino heptanoic acid, .beta.-aspartic acid, .gamma.-glutamic acid, cysteine (ACM), .epsilon.-lysine, .epsilon.-lysine (A-Fmoc), methionine sulfone, norleucine, norvaline, ornithine, d-ornithine, p-nitro-phenylalanine, hydroxy proline, and thioproline.

10. The composition according to claim 9, wherein said amino acid is selected from the group consisting of arginine, leucine, lysine, phenylalanine, tyrosine, valine, and phenylglycine.

11. The composition according to claim 1, wherein said peptide is selected from the group consisting of a di-peptide, a tri-peptide, a tetra-peptide, or a penta-peptide.

12. The composition according to claim 1, wherein said peptide comprises at least one naturally occurring amino acid.

13. The composition according to claim 1, wherein said peptide comprises at least one synthetic amino acid.

14. The composition according to claim 1, wherein said peptide comprises at least one .alpha.-amino acid.

15. The composition according to claim 1, wherein said peptide is formed from one or more amino acids selected from the group consisting of alanine, arginine, asparagine, aspartic acid, citrulline, cysteine, cystine, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, phenylglycine, proline, serine, threonine, tryptophan tyrosine, valine, hydroxy proline, .gamma.-carboxyglutamate, O-phosphoserine, .beta.-alanine, .alpha.-amino butyric acid, .gamma.-amino butyric acid, .alpha.-amino isobutyric acid, .epsilon.-amino caproic acid, 7-amino heptanoic acid, .beta.-aspartic acid, .gamma.-glutamic acid, cycteine (ACM), .epsilon.-lysine, .epsilon.-lysine (A-Fmoc), methionine sulfone, norleucine, norvaline, ornithine, d-ornithine, p-nitro-phenylalanine, hydroxy proline, and thioproline.

16. The composition according to claim 15, wherein said peptide is formed from one or more amino acids selected from the group consisting of arginine, leucine, lysine, phenylalanine, tyrosine, valine, and phenylglycine.

17. The composition according to claim 1, wherein said acylated aldehyde or acylated ketone is acylated by an acylating agent having the formula R--CO--X wherein R is alkyl, cycloalkyl, or aryl, and X is a leaving group.

18. The composition according to claim 17, wherein R is methyl, ethyl, cyclohexane, cyclopentane, phenyl or benzyl.

19. The composition according to claim 17, wherein R--CO is cyclohexyl, carboxyl, or acetyl.

20. A dosage unit form comprising

(A) a pharmacological composition according to claim 1; and

(B) (a) an excipient,

(b) a diluent,

(c) a disintegrant,

(d) a lubricant,

(e) a plasticizer,

(f) a colorant,

(g) a dosing vehicle, or

(h) any combination thereof.

21. A dosage unit form according to claim 20 comprising a tablet, a capsule, or a liquid.

22. A dosage unit form according to claim 20, wherein said dosing vehicle is selected from the group consisting of water, 1,2-propane diol, ethanol or any combination thereof.

23. A method for administering a biologically-active agent to a mammal in need of said agent, said method comprising administering orally to said mammal a composition as defined in claim 1.

24. A method for preparing an oral delivery pharmacological composition, said method comprising mixing:

(A) at least one biologically-active agent;

(B) a carrier comprising

(a) (i) at least one acylated aldehyde of an amino acid,

(ii) at least one acylated ketone of an amino acid,

(iii) at least one acylated aldehyde of a peptide,

(iv) at least one acylated ketone of a peptide, or

(v) any combination of (a)(i), (a)(ii), (a)(iii) and (a)(iv);

(b) (i) carboxymethyl-phenylalanine-leucine,

(ii) 2-carboxy-3-phenylpropionyl-leucine,

(iii) 2-benzylsuccinic acid, or

(iv) (phenylsulfonamido) phenylbutyric acid,

(v) or any combination of (b)(i), (b)(ii), (b)(iii) and (b)(iv); or

(c) a combination of (a) and (b); and

(C) optionally a dosing vehicles;

wherein said carrier is in an amount effective for oral delivery of said biologically-active agent.
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