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Generated: December 16, 2017

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Title: High affinity ssDNA ligands of HIV-1 reverse transcriptase
Abstract:Methods are described for the identification and preparation of DNA ligands to the HIV-1 reverse transcriptase protein. Included in the invention are specific ssDNA ligands to HIV-1 reverse transcriptase identified by the SELEX method. Also included are ssDNA ligands that inhibit HIV-1 reverse transcriptase.
Inventor(s): Schneider; Daniel J. (Boulder, CO), Gold; Larry (Boulder, CO), Feigon; Juli (Los Angeles, CA)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Filing Date:May 17, 1995
Application Number:08/443,407
Claims:1. A purified and isolated non-naturally occurring DNA ligand to HIV-1 reverse transcriptase wherein said ligand is selected from the group consisting of the sequences set forth in SEQ ID NOS: 6-72 and 76-94.
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Serving leading biopharmaceutical companies globally:

Medtronic
Daiichi Sankyo
Argus Health
AstraZeneca
McKinsey
Farmers Insurance
Merck
Citi
Mallinckrodt
Express Scripts

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