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Generated: July 26, 2017

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Title: Method of inhibiting the surface expression of glycolipid receptors for bacteria
Abstract:A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
Inventor(s): Platt; Frances M. (Oxford, GB), Neises; Gabrielle R. (Chesterfield, MO), Dwek; Raymond A. (Oxford, GB), Butters; Terry D. (Oxford, GB)
Assignee: Monsanto Company (St. Louis, MO)
Filing Date:May 20, 1996
Application Number:08/650,558
Claims:1. The method of inhibiting the surface expression of glycolipid receptors for bacteria comprising subjecting bacterial cells susceptible to said expression to an effective amount in vitro for inhibiting said expression of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.

2. The method of claim 1 in which the alkyl group contains from 4-6 carbon atoms.

3. The method of claim 1 in which the alkyl group is butyl.

4. The method of claim 1 in which the alkyl group is hexyl.

5. The method of claim 1 in which the inhibitory effective amount is from about 50 .mu.M to about 500 .mu.M.
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Fish and Richardson
Harvard Business School
Queensland Health
Merck
McKinsey
Mallinckrodt
Dow
Johnson and Johnson
Citi
Healthtrust

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