Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Merck
McKinsey
US Department of Justice
AstraZeneca
Accenture
Deloitte
Johnson and Johnson
Harvard Business School
UBS
Moodys

Generated: August 21, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title: Deoxygalactonojirimycin derivatives
Abstract:Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
Inventor(s): Platt; Frances M. (Oxford, GB), Neises; Gabrielle R. (Chesterfield, MO), Dwek; Raymond A. (Oxford, GB), Butters; Terry D. (Oxford, GB)
Assignee: Monsanto Company (St. Louis, MO)
Filing Date:Jan 17, 1996
Application Number:08/588,027
Claims:1. The method of inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of deoxygalactonojirimycin in which said alkyl contains from 3-6 carbon atoms.

2. The method of claim 1 in which the alkyl group contains from 4-6 carbon atoms.

3. The method of claim 2 in which the alkyl group is butyl.

4. The method of claim 2 in which the alkyl group is hexyl.

5. The method of claim 1 in which the inhibitory effective amount is from about 50 .mu.M to about 500 .mu.M.

6. The method of claim 1 in which the glycolipid is a glucoceramide based glycosphingolipid.

7. The method of claim 1 in which the glycolipid is a lysosomal glycolipid.

8. The method of claim 1 in which the glycolipid is a glucoceramide accumulating in cells affected with Gaucher's disease.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Citi
Moodys
US Army
AstraZeneca
Chubb
UBS
Merck
Fish and Richardson
Daiichi Sankyo
Cipla

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot