Generated: April 28, 2017
|Title:||Technetium-99m labeled peptides for imaging|
|Abstract:||This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.|
|Inventor(s):||Dean; Richard T. (Bedford, NH), Buttram; Scott (Derry, NH), McBride; William (Manchester, NH), Lister-James; John (Bedford, NH), Civitello; Edgar R. (Londonderry, NH)|
|Assignee:||Diatide, Inc. (Londonderry, NH)|
|Filing Date:||Jun 06, 1995|
|Claims:||1. A radiolabeled peptide for imaging sites within a mammalian body, comprising a specific binding peptide having an amino acid sequence and a radiolabel-binding moiety of formula: ##STR8## wherein X.dbd.H or a protecting group; |
(amino acid)=any amino acid;
the radiolabel-binding moiety is covalently linked to the peptide and wherein the radiolabel-binding moiety forms a complex with a radioisotope and the complex of the radiolabel-binding moiety and the radioisotope is electrically neutral.
2. The peptide of claim 1 wherein the amino acid is glycine and wherein X is an acetamidomethyl protecting group.
3. The peptide of claim 1 wherein the specific binding peptide and the radiolabel-binding moiety are covalently linked through one or more amino acids.
4. The peptide of claim 1 wherein the specific binding peptide is selected from the group consisting of peptides having the amino acid sequences:
GGGF.sub.D.Cpa.YW.sub.D KTFTamide ##STR9## [SYNRGDSTC(S-maleimido)CH.sub.2 CH.sub.2 --].sub.3 N GGGLRALVDTLKamide
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.