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Details for Patent: 5,759,997

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Details for Patent: 5,759,997

Title: Cyclosporin galenic forms
Abstract:Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.
Inventor(s): Cavanak; Thomas (Biel-Benken, CH)
Assignee: Novartis AG (Summit, NJ)
Filing Date:Jun 06, 1995
Application Number:08/471,301
Claims:1. A pharmaceutical composition for oral administration comprising cyclosporin A as active ingredient in a carrier medium comprising a mixture of monoglyerides, diglycerides and triglycerides and a reaction product of a natural or hydrogenated castor oil and ethylene oxide.

2. The composition of claim 1, wherein the amount of cyclosporin A is about 2.0 to about 20% by weight, based on the total weight of said composition.

3. The composition of claim 1, wherein said amount of monoglyceride is about 25 to about 50% by weight, based on the total weight of said monoglycerides, diglyerides and triglycerides.

4. The composition of claim 1, wherein said carrier medium further comprises ethanol.

5. The composition of claim 1, wherein said carrier medium further comprises a transesterification product of a natural vegetable oil triglyceride and a polyalkylene polyol.

6. The composition of claim 1, wherein said reaction product is a reaction product of a natural castor oil and ethylene oxide.

7. The composition of claim 1, wherein said reaction product is a reaction product of a hydrogenated castor oil and ethylene oxide.

8. A pharmaceutical composition for oral administration comprising cyclosporin A as active ingredient in a carrier medium comprising a mixture of monoglycerides, diglycerides and triglycerides, a reaction product of a natural or hydrogenated castor oil and ethylene oxide and a transesterification product of a natural vegetable oil triglyceride and a polyalkylene polyol.

9. The composition of claims 8, wherein the amount of cyclosporin A is about 2.0 to about 20% by weight, based on the total weight of said composition.

10. The composition of claim 8, wherein the amount of monoglyceride is about 25 to about 50% by weight, based on the total weight of said monoglycerides, diglycerides and triglycerides.

11. The composition of claim 8, wherein said reaction product is a reaction product of a natural castor oil and ethylene oxide.

12. The composition of claim 8, wherein said reaction product is a reaction product of a hydrogenated castor oil and ethylene oxide.
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