|Title:||Controlled release of steroids from sugar coatings|
|Abstract:||A sugar coating composition for application to a compressed medicinal tablet comprising a sugar, a dose of a hormonal steroid and a steroid release rate controlling amount of microcrystalline cellulose.|
|Inventor(s):||Barcomb; Reginald J. (Mooers Forks, NY)|
|Assignee:||American Home Products Corporation (Madison, NJ)|
|Filing Date:||Apr 10, 1996|
|Claims:||1. A sugar coating composition for application to a compressed medicinal tablet comprising a sugar, a loading dose of a hormonal steroid and a steroid release rate controlling amount of microcrystalline cellulose. |
2. A sugar coating composition of claim 1 in which the sugar is sucrose.
3. A sugar coating composition of claim 1 in which said hormonal steroid is medroxyprogesterone acetate, levonorgestrel, gestodene, medrogestone, estradiol, estriol, ethinylestradiol, mestranol, estrone, dienestrol, hexestrol, diethylstilbestrol, progesterone, desogestrel, norgestimate, hydroxyprogesterone, norethindrone, norethindone acetate, norgestrel, megestrol acetate, methyltestosterone, ethylestrenol, methandienone, oxandrolone or trimegestone.
4. A sugar coating composition of claim 1 comprising sucrose, from about 0.1% to about 3% microcrystalline cellulose, by weight, polyvinylpyrrolidone in an amount of from 0 to about 5% by weight, a hormonal steroid in an amount of from about 0.1 to about 20% by weight and water of solution.
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