|Abstract:||1.alpha.-Hydroxy-24-epi-vitamin D.sub.4 and novel intermediates formed in a novel method of preparing this compound. The method includes campesterol as a starting material which is converted to 24-epi-vitamin D.sub.4 which is in turn hydroxylated to 1.alpha.-hydroxy-24-epi-vitamin D.sub.4 via tosylated and cyclic derivatives of 24-epi-vitamin D.sub.4. 1.alpha.-Hydroxy-24-epi-vitamin D.sub.4 has been found to be bioactive.|
|Inventor(s):||Knutson; Joyce C. (Madison, WI), Moriarty; Robert M. (Oak Park, IL), Penmasta; Raju (Oak Park, IL), Bishop; Charles W. (Verona, WI)|
|Assignee:||Bone Care International, Inc. (Madison, WI)|
|Filing Date:||Sep 07, 1995|
|Claims:||1. The compound of the formula (I): ##STR3## wherein R.sub.1 is either hydrogen or tosyl and R.sub.2 is either hydrogen or hydroxy, or a salt, hydrate, or solvate thereof. |
2. The compound of claim 1, wherein the compound is 1.alpha.-hydroxy-24-epi-vitamin D.sub.4.
3. 5,6-trans-1.alpha.-hydroxy-24-epi-vitamin D.sub.4.
4. 24-epi-vitamin D.sub.4 tosylate.