|Title:|| Method of treatment for benign prostatic hyperplasia|
|Abstract:||Disclosed is an improved treatment for men with benign prostatic hyperplasia (BPH), involving combination therapy of a 5.alpha.-reductase inhibitor, e.g. a 17.beta.-substituted 4-azasteroid, a 17.beta.-substituted non-azasteroid, 17.beta.-acyl-3-carboxy-androst-3,5-diene, benzoylaminophenoxybutanoic acid derivative, fused benz(thio)amide or cinnamoylamide derivative, aromatic 1,2-diethers or thioethers, aromatic ortho acylaminophenoxy alkanoic acids, ortho thioalkylacylaminophenoxy alkanoic acids, pharmaceutically acceptable salts and esters thereof, and particularly finasteride, in combination with an .alpha..sub.1 -adrenergic receptor blocker, i.e., terazosin. The combination provides therapy at the molecular level for the underlying cause of the disease as well as providing symptomatic relief. Pharmaceutical compositions useful for treatment are also disclosed.|
|Inventor(s):|| Gormley; Glenn J. (Westfield, NJ), Stoner; Elizabeth (Westfield, NJ) |
|Assignee:|| Merck & Co., Inc. (Rahway, NJ) |
|Filing Date:||Apr 25, 1995|
|Claims:||1. A method of treating benign prostatic hyperplasia in a patient with an enlarged prostate comprising the administration of a synergistically therapeutically effective amounts of finasteride in combination with terazosin. |
2. A pharmaceutical composition for the treatment of benign prostatic hyperplasia in a patient with an enlarged prostate comprising a synergistically therapeutically effective amounts of finasteride and terazosin and a pharmaceutically acceptable carrier.