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Details for Patent: 5,747,545

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Title:	Method of preventing NMDA receptor complex-mediated Neuronal damage
Abstract:	Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection.
Inventor(s):	Lipton; Stuart A. (Newton, MA)
Assignee:	The Children's Medical Center Corporation (Boston, MA)
Filing Date:	Mar 22, 1995
Application Number:	08/407,973
Claims:	1. A method for a preliminary screen of candidate NMDA channel antagonists for safety and efficacy, said method comprising a) determining the time period required for the candidate to induce blockade of NMDA-receptor-associate ion channels; b) determining the time period required for loss of said blockade of ion channels when administration of the compound ceases; and c) selecting a compound with time periods (a) and (b) that are shorter than the time periods characteristic of MK-801, thereby enhancing the prospect that the candidate will be a clinically tolerated selective NMDA antagonist.