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|Title:||Method of preventing NMDA receptor complex-mediated Neuronal damage|
|Abstract:||Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection.|
|Inventor(s):||Lipton; Stuart A. (Newton, MA)|
|Assignee:||The Children's Medical Center Corporation (Boston, MA)|
|Filing Date:||Mar 22, 1995|
|Claims:||1. A method for a preliminary screen of candidate NMDA channel antagonists for safety and efficacy, said method comprising |
a) determining the time period required for the candidate to induce blockade of NMDA-receptor-associate ion channels;
b) determining the time period required for loss of said blockade of ion channels when administration of the compound ceases; and
c) selecting a compound with time periods (a) and (b) that are shorter than the time periods characteristic of MK-801, thereby enhancing the prospect that the candidate will be a clinically tolerated selective NMDA antagonist.
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