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Generated: June 26, 2017
| Title: | Method of preventing NMDA receptor complex-mediated Neuronal damage |
| Abstract: | Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection. |
| Inventor(s): | Lipton; Stuart A. (Newton, MA) |
| Assignee: | The Children's Medical Center Corporation (Boston, MA) |
| Filing Date: | Mar 22, 1995 |
| Application Number: | 08/407,973 |
| Claims: | 1. A method for a preliminary screen of candidate NMDA channel antagonists for safety and efficacy, said method comprising a) determining the time period required for the candidate to induce blockade of NMDA-receptor-associate ion channels; b) determining the time period required for loss of said blockade of ion channels when administration of the compound ceases; and c) selecting a compound with time periods (a) and (b) that are shorter than the time periods characteristic of MK-801, thereby enhancing the prospect that the candidate will be a clinically tolerated selective NMDA antagonist. |
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