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Generated: December 18, 2017

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Title: Reduction of anthracycline-induced cardiotoxicity
Abstract:Disclosed is a method for preventing cardiotoxicity in a human in need of such preventive treatment, the method including administering an effective amount of a bisdioxopiperazine. Also disclosed is a method for preventing cardiotoxicity induced by the administration of an anthracycline. Further, a tumoricidal, cardioprotective combination of agents is disclosed.
Inventor(s): Speyer; James Leonard (New York, NY), Muggia; Franco Mario (Los Angeles, CA), Green; Michael David (North Carlton, AU)
Assignee: New York University (New York, NY)
Filing Date:Sep 03, 1993
Application Number:08/116,399
Claims:1. A biologically effective human anti-neoplastic composition, comprising in admixture:

an anthracycline; and

a cardioprotective amount of (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane.

2. The composition of claim 1 wherein said anthracycline is doxorubicin.

3. A biologically effective human anti-neoplastic composition comprising in admixture:

an anthracycline; and

(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane, said composition formulated such that after administration of said composition, a cardioprotective amount of said (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane becomes bioavailable before an effective amount of said anthracycline becomes bioavailable.

4. The composition of claim 3 wherein said anthracycline is doxorubicin.

5. A pharmaceutical dosage form comprising a biologically effective human anti-neoplastic composition,

wherein said composition comprises:

an anthracycline in admixture with

a cardioprotective amount of (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane.

6. The pharmaceutical dosage form according to claim 5, wherein said dosage form is a solution suitable for intravenous administration.

7. The pharmaceutical dosage form according to claim 5, wherein said composition is formulated such that after administration of said composition a cardioprotective amount of said (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane becomes bioavailable before an effective amount of said anthracycline becomes bioavailable.

8. The pharmaceutical dosage form according to claim 7, wherein said dosage form is a solution suitable for intravenous administration.
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