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Details for Patent: 5,731,319

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Details for Patent: 5,731,319

Title: Methods for treating disorders using descarboethoxyloratadine
Abstract:Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines.
Inventor(s): Aberg; A. K. Gunnar (Westborough, MA), McCullough; John R. (Worcester, MA), Smith; Emil R. (Shrewsbury, MA)
Assignee: Sepracor Inc. (Marlborough, MA) University of Massachusetts (Boston, MA)
Filing Date:Jan 13, 1997
Application Number:08/783,393
Claims:1. A method of treating allergic asthma in a human while avoiding the concomitant liability of adverse side-effects associated with the administration of non-sedating antihistamines, comprising administering to said human a therapeutically effective amount of DCL or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 wherein said adverse side-effect is cardiac arrhythmia or tumor promotion.

3. The method of claim 1 wherein said human has a higher than normal propensity for or incidence of cancer.

4. The method of claim 1, wherein interaction between DCL and a drug that inhibits cytochrome P450 is avoided.

5. The method of claim 1 wherein the amount of DCL administered is from about 0.1 mg to less than about 10 mg per day.

6. The method of claim 5 wherein the amount of DCL administered is from about 0.1 mg to about 5 mg per day.

7. The method of claim 1 wherein the amount of said DCL or a pharmaceutically acceptable salt thereof is administered together with a pharmaceutically acceptable carrier.
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