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Generated: September 26, 2017

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Title: Transdermal and trans-membrane delivery compositions
Abstract:The rate of absorption of drugs across skin and other body membranes such as mucous membranes and the blood brain barrier is enhanced by adding to the drug composition a compound which enhances the rate. This compound may be a macrocyclic ester, diester, amide, diamide, amidine, diamidine, thioester, dithioester, thioamide, ketone or lactone. The macrocyclic ketone contains at least 12 carbon atoms.
Inventor(s): Hsieh; Dean (Brandamore, PA)
Assignee: Conrex Pharmaceutical Corporation (Phoenixville, PA)
Filing Date:Dec 22, 1994
Application Number:08/361,833
Claims:1. A composition which is effective in enhancing the qualities of skin and which comprises: (A) a skin-treating compound; (B) a compound having the structure: ##STR5## wherein X and Y are oxygen, sulfur or an imino group of the structure.dbd.N--R, with the proviso that when Y is an imino group, X is an imino group, and when Y is sulfur, X is sulfur or an imino group, A is a group having the structure ##STR6## wherein X and Y are as defined above, m and n are integers having a value from 1 to 20 and the sum of m+n is not greater than 25, p is an integer having a value of 0 or 1, q is an integer having a value of 0 or 1, r is an integer having a value of 0 or 1, and R is hydrogen or an alkyl group which has from 1 to 6 carbon atoms and which may be straight chained or branched, with the proviso that when p, q and r are 0 and Y is oxygen, m+n is at least 11; (C) a carrier; and optionally (D) a cosmetic additive.

2. A composition according to claim 1 comprising about 0.1 to about 10 wt. % of said skin-treating compound and about 0.1 to about 30 wt. % of said compound (B).

3. A composition according to claim 2 comprising about 0.5 to about 3 wt. % of said skin-treating compound and about 0.5 to about 10 wt. % of said compound (B).

4. A composition according to claim 3 comprising about 2 to about 5 wt. % of said compound (B).

5. A composition according to claim 2 which is an anti-oxidant composition and wherein the skin-treating compound includes an anti-oxidant material.

6. A composition according to claim 5 wherein said compound of (B) is cyclopentadecanolide.

7. A composition according to claim 2 wherein said compound (B) is cyclopentadecanolide.
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