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Details for Patent: 5,726,315

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Details for Patent: 5,726,315

Title: Certain 3-hydroxy-6-hydroxymethyl-pyridine intermediates
Abstract:The compounds of the invention are tri-substituted pyridine intermediates, useful in the preparation of final products, wherein said final products are involved in the preparation of medicaments. Said medicaments are useful for the treatment of various diseases including psoriasis. A compound of the formula (II): ##STR1## wherein R.sup.1 is hydrogen, benzyl or a group of the formula (A): ##STR2## in which n is 1 to 20; and R.sup.5 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or trifluoromethyl; and R.sup.7 is a leaving group consisting of halogen, OTf or (Trifluorate, e.g. OSO.sub.2 CF.sub.3), OSO.sub.2 alkyl and OSO.sub.2 Ar wherein Ar represents optionally substituted aryl.
Inventor(s): Sheldrake; Peter William (Tunbridge Wells, GB2), Powling; Laurence Charles (Maidstone, GB2), Bickle; Peter William (Auckland, NZ)
Assignee: SmithKline Beecham plc (GB2)
Filing Date:May 23, 1996
Application Number:08/569,249
Claims:1. A compound of formula (II): ##STR16## R.sup.1 is hydrogen or a group of formula (A): ##STR17## where n is 1 to 20 and R.sup.5 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or trifluoromethyl; and

R.sup.7 is a leaving group selected from the group consisting of halogen, OTf or (Triflate, e.g. OSO.sub.2 CF.sub.3), OSO.sub.2 C.sub.1 -C.sub.6 alkyl or OSO.sub.2 Ar where Ar is optionally substituted aryl.

2. A compound according to claim 1 wherein R.sup.1 is a group of formula (A) where n is 1-20, R.sup.5 is C.sub.1-6 alkoxy, and R.sup.7 is halogen, OTf or OSO.sub.2 Ar where Ar is optionally substituted aryl.

3. A compound according to claim 2 wherein R.sup.5 is methoxy, n is 2 to 8, and R.sup.7 is bromo or iodo.
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