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|Title:||Method of forming a biodegradable film dressing on tissue|
|Abstract:||The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer such as polylactides, polyglycolides, polycaprolactones or copolymers thereof in a pharmaceutically acceptable solvent such as N-methylpyrrolidone, alcohols or alkyl esters. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid such as water, saline solution or body fluid to coagulate or solidify the film onto the human or animal tissue. The biodegradable film can be used to protect and to promote healing of injured tissue and/or to deliver biologically active agents such as growth.|
|Inventor(s):||Tipton; Arthur J. (Fort Collins, CO), Fujita; Shawn M. (Fort Collins, CO), Dunn; Richard L. (Fort Collins, CO)|
|Assignee:||Atrix Laboratories, Inc. (Fort Collins, CO)|
|Filing Date:||Nov 08, 1994|
|Claims:||1. A method of forming an in situ microporous biodegradable film dressing on human or animal tissue, comprising: |
(a) dispensing an effective amount of a liquid polymer composition on the tissue, the liquid polymer composition having a formulation of,
(i) a biodegradable or bioerodible thermoplastic polymer insoluble in an aqueous based fluid; and
(ii) an organic solvent miscible to dispersible in the aqueous based fluid; and
(b) contacting the liquid polymer composition with the aqueous based fluid that is applied to the tissue before dispensing step (a) and to the liquid polymer composition after dispensing step (a) to coagulate or solidify the composition to form the film dressing on the tissue.
2. The method of claim 1, wherein the dispensing step includes spraying, painting, or squirting the liquid polymer composition on the tissue.