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|Title:||Technetium-99M labeled peptides for imaging|
|Abstract:||This invention relates to radiolabel binding moieties for producing radiolabeled peptides and methods for making such peptides. Specifically, the invention relates to picolinic acid or picolinamine containing radiolabel binding moieties, peptides radiolabeled therewith and methods of making and using both the radiolabel binding moieties and peptides radiolabeled therewith.|
|Inventor(s):||Dean; Richard T. (Bedford, NH), Buttram; Scott (Derry, NH), McBride; William (Manchester, NH), Lister-James; John (Bedford, NH), Civitello; Edgar R. (Londonderry, NH)|
|Assignee:||Diatide, Inc. (Londonderry, NH)|
|Filing Date:||Jun 06, 1995|
|Claims:||1. A composition of matter comprising a radiolabel-binding moiety of formula: ##STR8## wherein X=H or a protecting group; (amino acid)=any amino acid; and |
wherein the radiolabel-binding moiety forms a complex with a radioisotope, and the complex of the radiolabel-binding moiety and the radioisotope is electrically neutral.
2. The composition of matter of claim 1 wherein the (amino acid) is glycine and wherein X is an acetamidomethyl protecting group.