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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Mallinckrodt
McKinsey
Healthtrust
Fish and Richardson
Accenture
Boehringer Ingelheim
UBS
Julphar
Novartis

Generated: November 23, 2017

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Title: Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents
Abstract:Compounds of the formula ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.2 is H, C.sub.1 -C.sub.6 alkyl optionally substituted by OH, C.sub.1 -C.sub.3 alkoxy or C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.3 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 perfluoroalkyl or (C.sub.3 -C.sub.6 cycloalkyl)C.sub.1 -C.sub.6 alkyl; and Y is chloro, bromo, or fluoro. The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.
Inventor(s): Bell; Andrew Simon (Groton, CT), Brown; David (Groton, CT), Terrett; Nicholas Kenneth (Groton, CT)
Assignee: Pfizer Inc. (New York, NY)
Filing Date:Jun 24, 1994
Application Number:08/265,295
Claims:1. A compound of the formula: ##STR49## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl;

R.sup.2 is H, C.sub.1 -C.sub.6 alkyl optionally substituted by OH, C.sub.1 -C.sub.3 alkoxy or C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.3 perfluoroalkyl;

R.sup.3 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 perfluoroalkyl or (C.sub.3 -C.sub.6 cycloalkyl) C.sub.1 -C.sub.6 alkyl; and Y is chloro, bromo or fluoro.
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Serving leading biopharmaceutical companies globally:

Fish and Richardson
McKesson
AstraZeneca
Citi
UBS
Chinese Patent Office
Cipla
Queensland Health
Chubb
US Army

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