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Details for Patent: 5,716,962

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Details for Patent: 5,716,962

Title: Process for therapeutically modifying and resetting prolactin rhythm with a dopamine agonist
Abstract:A process for the long term modification and regulation of lipid and carbohydrate metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these are the hallmarks of noninsulin dependent, or Type II diabetes)--by administration (i.e., by oral, sublingual or parenternal administration) to a vertebrate, animal or human, of a dopamine agonist, e.g., bromocriptine. Administration of the bromocriptine is made over a limited period at a time of day dependent on the normal circadian rhythm of insulin resistant and insulin sensitive members of a similar species. Insulin resistance, and hyperinsulinemia and hyperglycemia, or both, can be controlled in humans on a long term basis by such treatment inasmuch as the short term daily administration resets hormonal timing in the neural centers of the brain to produce long term effects.
Inventor(s): Cincotta; Anthony H. (Andover, MA), Meier; Albert H. (Baton Rouge, LA)
Assignee: The Board of Supervisors of Louisiana State University and Agricultural (Baton Rouge, LA)
Filing Date:Jun 06, 1995
Application Number:08/465,820
Claims:1. A process for therapeutically modifying and resetting the prolactin rhythm of a human subject which comprises administering to a human in need of treatment, a dopamine agonist on a daily basis at an hour, in amount, and for a period sufficient that the glucose disposal effects of insulin in a human will be increased and hyperglycemia decreased.

2. The process of claim 1 wherein the dopamine agonist is administered to the human to reduce hyperinsulinemia.
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