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Generated: November 21, 2017

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Title: GABA and L-glutamic acid analogs for antiseizure treatment
Abstract:A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
Inventor(s): Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI), Sobieray; Denis Martin (Holland, MI), Franklin; Lloyd Charles (Hamilton, MI), Schwindt; Mark Alan (Holland, MI)
Assignee: Northwestern University (Evanston, IL)
Filing Date:Oct 16, 1996
Application Number:08/733,102
Claims:1. A compound which is 5-methyl-3-[[[(4-methylphenyl) sulfonyl]oxy]-methyl]-hexanoic acid, phenylmethyl ester, or

5-methyl-3-[[[(4-methylphenyl) sulfonyl]oxy]-methyl]-hexanoic acid, 1,1 -dimethylethyl ester.
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Express Scripts
Boehringer Ingelheim
US Army
AstraZeneca
Mallinckrodt
Healthtrust
Covington
Merck
Argus Health
Johnson and Johnson

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