|Title:||GABA and L-glutamic acid analogs for antiseizure treatment|
|Abstract:||A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.|
|Inventor(s):||Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI), Sobieray; Denis Martin (Holland, MI), Franklin; Lloyd Charles (Hamilton, MI), Schwindt; Mark Alan (Holland, MI)|
|Assignee:||Northwestern University (Evanston, IL)|
|Filing Date:||Oct 16, 1996|
|Claims:||1. A compound which is 5-methyl-3-[[[(4-methylphenyl) sulfonyl]oxy]-methyl]-hexanoic acid, phenylmethyl ester, or |
5-methyl-3-[[[(4-methylphenyl) sulfonyl]oxy]-methyl]-hexanoic acid, 1,1 -dimethylethyl ester.