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Details for Patent: 5,709,861

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Details for Patent: 5,709,861

Title: Compositions for the delivery of antigens
Abstract:The present invention relates to the delivery of antigens. Delivery systems are provided that include the antigen and acylated or sulfonated amino acids or poly amino acids. Methods of preparation and administration of these compositions are also provided.
Inventor(s): Santiago; Noemi B. (Hawthorne, NY), Haas; Susan (Monsey, NY), Leone-Bay; Andrea (Ridgefield, CT), Milstein; Sam J. (Larchmont, NY), Barantsevitch; Evgueni (New Rochelle, NY)
Assignee: Emisphere Technologies, Inc. (Hawthorne, NY)
Filing Date:Jan 13, 1995
Application Number:08/372,208
Claims:1. A composition comprising:

(a) an antigen; and

(b) at least one carrier comprising a member selected from the group consisting of:

(i) an acylated amino acid;

(ii) a poly amino acid comprising at least one acylated amino acid;

(iii) a sulfonated amino acid;

(iv) a poly amino acid comprising at least one sulfonated amino acid; or

(v) any combination thereof.

2. A composition as defined in claim 1, comprising a mixture.

3. A composition as defined in claim 1, comprising a microsphere.

4. A composition as defined in claim 1, wherein said antigen comprises a peptide.

5. A composition as defined in claim 1, wherein said carrier comprises an acylated amino acid.

6. A composition as defined in claim 1, wherein said carrier comprises a poly amino acid comprising at least one acylated amino acid.

7. A composition as defined in claim 1, wherein said carrier comprises a sulfonated amino acid.

8. A composition as defined in claim 1, wherein said carrier comprises a poly amino acid comprising at least one sulfonated amino acid.

9. A composition comprising:

(a) ovalbumin; and

(b) at least one carrier comprising a member selected from the group consisting of:

(i) an acylated amino acid;

(ii) a poly amino acid comprising at least one acylated amino acid;

(iii) a sulfonated amino acid;

(iv) a poly amino acid comprising at least one sulfonated amino acid; or

(v) any combination thereof.

10. A dosage unit form comprising

(A) a composition as defined in claim 1; and

(B) (a) an excipient,

(b) a diluent,

(c) a disintegrant,

(d) a lubricant,

(e) a plasticizer,

(f) a colorant,

(g) a dosing vehicle, or

(h) any combination thereof.

11. A dosage unit form as defined in claim 10 comprising a tablet, a capsule, or a liquid.

12. A method for administering an antigen to an animal, said method comprising orally administering to said mammal a composition as defined in claim 1.

13. A method for preparing a composition as defined in claim 1, said method comprising mixing an antigen, and a carrier comprising a member selected from the group consisting of:

(i) an acylated amino acid;

(ii) a poly amino acid comprising at least one acylated amino acid;

(iii) a sulfonated amino acid;

(iv) a poly amino acid comprising at least one sulfonated amino acid; or

(v) any combination thereof.
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