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|Title:||Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds|
|Abstract:||The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.|
|Inventor(s):||Liotta; Dennis C. (McDonough, GA), Schinazi; Raymond F. (Decatur, GA), Choi; Woo-Baeg (North Brunswick, NJ)|
|Assignee:||Emory University (Atlanta, GA)|
|Filing Date:||Jun 07, 1995|
|Claims:||1. A liposomal suspension that includes .beta.-2'-deoxy-5-fluoro-3'-thiacytidine. |
2. A liposomal suspension that includes the phosphate ester of .beta.-2'-deoxy-5-fluoro-3'-thiacytidine.
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