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Generated: November 24, 2017

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Title: Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
Abstract:The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.
Inventor(s): Liotta; Dennis C. (McDonough, GA), Schinazi; Raymond F. (Decatur, GA), Choi; Woo-Baeg (North Brunswick, NJ)
Assignee: Emory University (Atlanta, GA)
Filing Date:Jun 07, 1995
Application Number:08/481,556
Claims:1. A liposomal suspension that includes .beta.-2'-deoxy-5-fluoro-3'-thiacytidine.

2. A liposomal suspension that includes the phosphate ester of .beta.-2'-deoxy-5-fluoro-3'-thiacytidine.
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Cerilliant
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AstraZeneca
QuintilesIMS
US Army

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