.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,693,626

« Back to Dashboard

Details for Patent: 5,693,626

Title: Tetrahydrofuran antifungals
Abstract:A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two phosphate ester groups (e.g., a phosphate ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
Inventor(s): Saksena; Anil K. (Upper Montclair, NJ), Girijavallabhan; Viyyoor M. (Parsippany, NJ), Lovey; Raymond G. (West Caldwell, NJ), Pike; Russell E. (Stanhope, NJ), Wang; Haiyan (Dayton, NJ), Liu; Yi-Tsung (Morris Township, NJ), Ganguly; Ashit K. (Upper Montclair, NJ), Bennett; Frank (Piscataway, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Filing Date:Jun 02, 1995
Application Number:08/459,145
Claims:1. A compound represented by the formula I ##STR109## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl;

R.sub.1 is a straight or branched chain (C.sub.4 to C.sub.5) alkyl group substituted by an ester or an ether group or a pharmaceutically acceptable salt thereof.

2. A compound of claim 1 wherein R.sub.1 is a C.sub.4 -or C.sub.5 -alkyl group selected from: --H(C.sub.2 H.sub.5)H(R.sub.4)CH.sub.3, --H(C.sub.2 H.sub.5)CH.sub.2 CH.sub.2 R.sub.4, --(CH.sub.2).sub.2 H(R.sub.4)C.sub.2 H.sub.5, --H(CH.sub.3)H(R.sub.4)CH.sub.3, --H(C.sub.2 H.sub.5)CH.sub.2 R.sub.4 and --H(CH.sub.3)CH.sub.2 Ch.sub.2 R.sub.4

wherein R.sub.4 is an ester group or an ether group and the carbons with the asterisk(*) have the R or S absolute configuration or a pharmaceutically acceptable salt thereof.

3. A compound represented by formula III ##STR110## wherein R.sub.5 is ##STR111## wherein R.sub.12 is an ester group or an ether group or a pharmaceutically acceptable salt thereof.

4. A compound represented by the formula IV ##STR112## wherein R.sub.9 =--H(C.sub.2 H.sub.5)CH(R.sub.6)CH.sub.3 or --H(CH.sub.3)CH(R.sub.6)CH.sub.3 wherein R.sub.6 is an ester group or an ether group.

5. A compound of claim 4 which is ##STR113## or a pharmaceutically acceptable salt thereof.

6. A compound of claim 1 wherein the ester group is a polyether ester, a phosphate ester, a heterocyclic ester, an alkanoate ester, an alkenoate ester, an amino acid acid ester, an acid ester, or a sulfate ester.

7. A compound of claim 1 wherein R.sub.1 is a straight or branched chain (C.sub.4 -C.sub.5) alkyl group substituted by an ester group.

8. A compound of claim 4 wherein the ester group is a polyether ester, a phosphate ester, a heterocyclic ester, an alkanoate ester, an alkenoate ester, an amino acid acid ester, an acid ester, or a sulfate ester.

9. A pharmaceutical composition for treating or preventing fungal infection comprising an antifungally effective amount of a compound of claim 1 together with a pharmaceutically acceptable carrier therefor.

10. A method of treating and/or preventing fungal infections in a mammal afflicted with same which comprises administering an antifungally effective amount of a compound of claim 1 sufficient for such treating or preventing.

11. The pharmaceutical composition of claim 9 wherein the mode of administration is oral or parenteral.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc