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Details for Patent: 5,693,321

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Details for Patent: 5,693,321

Title: Polymers containing diester units
Abstract:The present invention relates to the process for the preparation of a biodegradable polymer comprising diester units of the formula (III) where R.sup.1 and R.sup.2 each represents a hydrogen atom or a carbon-attached monovalent organic group or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group; m and n, which may be the same or different, are 0 or 1; and R.sup.3 is a carbon-attached divalent organic grouping.
Inventor(s): Klaveness; Jo (Oslo, NO), Strande; Per (Oslo, NO), Wiggen; Unni Nordby (Rasta, NO)
Assignee: Nycomed Imaging AS (Oslo, NO)
Filing Date:Jun 02, 1995
Application Number:08/458,612
Claims:1. A process for the preparation of a biodegradable polymer comprising diester units of the formula (III) ##STR14## where R.sup.1 and R.sup.2 each represents a hydrogen atom or a carbon-attached monovalent organic group or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group; m and n, which may be the same or different, are 0 or 1; and R.sup.3 is a carbon-attached divalent organic grouping; which comprises one or more of the following steps:

(A) condensation polymerizing a compound of formula (VI)

where R.sup.8 represents a metal ion and X represents a leaving group reactive therewith, to yield a homopolymer comprising diester units of formula (III) where n is 0;

(B) condensing a compound of formula (XII)

with a compound of formula (XIII)

to yield a homopolymer comprising diester units of formula (III) where m and n are 0;

(C) condensation polymerizing a compound of formula

where R.sup.3A and R.sup.3B each represent carbon-attached divalent groupings and R.sup.9 represents O or a group --NR.sup.4 in which R.sup.4 is selected from the group consisting of a hydrogen atom, an acyl group and a carbon-attached hydrocarbyl group, to yield a homopolymer comprising diester units of formula (III) where R.sup.3 represents a group --R.sup.3B --CO--R.sup.9 --R.sup.3A --;

(D) reacting a compound of formula

with phosgene in the presence of a base, to yield a homopolymer comprising diester units of formula (III) where m and n are 1 and R.sup.3 represents a group --C(R.sup.1 R.sup.2)--;

(E) reacting a compound of formula

and a compound of formula

with phosgene in the presence of a base, to yield a homopolymer comprising diester units of formula (III) where m and n are 1; and

(F) reacting a compound of the formula (XXI)

where R.sup.10 and R.sup.11, optionally together with the groups R.sup.3A and R.sup.3B to which they are attached, each represent reactive functional groupings, with a compound of the formula (XXII)

where R.sup.3C represents a carbon-attached divalent organic grouping and R.sup.12 and R.sup.13 are each selected from the group consisting of functional groupings reactive with said groups R.sup.10 and R.sup.11 or R.sup.10 --R.sup.3A -- and R.sup.11 --R.sup.3B -- and polymerizable groups capable of interaction with said groups R.sup.10 and R.sup.11 or R.sup.10 --R.sup.3A -- and R.sup.11 --R.sup.3B --, to yield a polymer comprising diester units of formula (III).
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