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Details for Patent: 5,688,794

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Details for Patent: 5,688,794

Title: Method for modifying or regulating lipid metalolism in an animal or human subject with a proclactin stimulating compound
Abstract:A process for the long term modification and regulation of lipid and glucose metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these being the hallmarks of non-insulin dependent, or Type II diabetes)--by administration to a vertebrate, animal or human, or a prolactin stimulating compound.
Inventor(s): Meier; Albert H. (Baton Rouge, LA), Cincotta; Anthony H. (Andover, MA)
Assignee: Ergo Science Incorporated (Charlestown, MA) Board of Supervisors of Louisiana State University and Agricultural and (Baton Rouge, LA)
Filing Date:Oct 31, 1995
Application Number:08/551,063
Claims:1. A method for modifying or regulating lipid metabolism in an animal or human subject in need of such treatment comprising

administering to said subject a prolactin stimulating compound on a timed daily basis at a predetermined time of day and in a dosage amount and for a period of time sufficient to achieve in said subject at least one of the following modifications: reduction in hypercholesterolemia and reduction of hypertriglyceridemia.

2. A method for modifying or regulating lipid metabolism in an animal or human subject exhibiting hypercholesterolemia or hypertriglyceridemia comprising:

administering a prolactin-stimulating compound daily to said subject at a time from about two hours to about four hours prior to the time at which the prolactin bloodstream level peaks in a lean member of the same species and sex as said subject, wherein said lean member is not exhibiting hypercholesterolemia or hypertriglyceridemia, in a dosage amount within the range from about 10 micrograms to about 100 micrograms per pound body weight, wherein said compound is administered for a period of time sufficient to achieve in said subject a decrease in either hypercholesterolemia or hypertriglyceridemia.

3. The method of claim 1 wherein at least one modification persists over a long term after cessation of administration of the prolactin stimulating compound.

4. The method of claim 2 wherein at least one modification persists over a long term after cessation of administration of the prolactin stimulating compound.

5. The method of claim 1 wherein the period of administration of said prolactin stimulating compound is sufficient to modify and reset the neural phase oscillations controlling the prolactin bloodstream levels of said subject.

6. The method of claim 2 wherein the period of administration of said prolactin stimulating compound is sufficient to modify and reset the neural phase oscillations controlling the prolactin bloodstream levels of said subject.

7. The method of claim 1 wherein said prolactin stimulating compound is metoclopramide.

8. The method of claim 2 wherein said prolactin stimulating compound is metoclopramide.

9. The method of claim 3 wherein said prolactin stimulating compound is metoclopramide.

10. The method of claim 4 wherein said prolactin stimulating compound is metoclopramide.

11. The method of claim 5 wherein said prolactin stimulating compound is metoclopramide.

12. The method of claim 6 wherein said prolactin stimulating compound is metoclopramide.
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