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Details for Patent: 5,688,769

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Details for Patent: 5,688,769

Title: Treatment method
Abstract:A method for inhibiting ovarian steroidogenesis in women comprising administering to women an ovarian steroidogenesis inhibitorilly effective amound of D Ser (tbu).sup.6 des Gly NH.sub.2 .sup.10 LH-RH ethylamide.
Inventor(s): Labrie; Fernand (Quebec, CA), Raynaud; Jean-Pierre (Paris, FR)
Assignee: Uclaf; Roussel (FR)
Filing Date:Nov 30, 1994
Application Number:08/347,054
Claims:1. A method for inhibiting ovarian steroidogenesis in women comprising administering to normal women with regular menstrual cycles an ovarian steroidogenesis inhibitorally effective amount of at least one peptide of the formula

wherein (a) Z is Gly-NH.sub.2, Y is Leu and X is Gly, (b) Z is Gly-NH.sub.2, Y is Leu, X is DN Leu, DN Val, D Abu (.alpha.-aminobutyric acid), D Phe, D Ser, D Thr, D Met, D Pgl, D Lys, Leu, Ile, Nle, Val, N-Val, Met, Phe, D Leu, D Arg, D ser (tbu), D Thr (tbu), D Cys (tbu), D Asp (O tbu), D Glu (Otbu), D Orn (boc), D Lys (boc), D Trp, Trp, 2-methyl Ala, D Tyr, D Met, .epsilon.-lauryl D Lys, .epsilon.-dextran-D Lys, (c) Z is NH-cyclopropyl- or NH-Alk wherein Alk is alkyl of 1 to 3 carbon atoms, Y is Leu and X is D Ser (tbu), D Thr (tbu), D Asp (Otbu), D Glu (Otbu), D Orn (boc), D Lys (boc), (d) Z is --NH--CH.sub.3, --NH--CH.sub.2 --CH.sub.3,--NH--CH.sub.2 --CH.sub.2 --CH.sub.3, --NH--C.H.sub.2 --CH.sub.2 --OH, ##STR2## Y is Leu and X is Gly, (e) Z is --NH--CH.sub.2 --CH.sub.3, Y is Leu and X is D Trp, D Leu, D Ala, D Ser (tbu), D Tyr, D Lys, Ala, (f) Z is Gly-NH.sub.2 or --NH--CH.sub.2 --CH.sub.3, Y is N.alpha.Met Leu and X is Gly (g) Z is --NH-cyclopropyl, Y is Leu and X is D Leu or (h) Z is Gly-NH.sub.2, --NH-cyclopropyl or --NHAlk' where Alk' is alkyl of 1 to 3 carbon atoms, Y is Ser (but), Cys (but), Asp (Obut), Glu (Obut), --Orn (boc), Lys (boc) and X is Gly.

2. A method for inhibiting ovarian steroidogenesis in women comprising administering to women with regular menstrual cycles an ovarian steroidogenesis inhibitorally effective amount of D Ser (tbu).sup.6 des Gly NH.sub.2 .sup.10 LH-RH ethylamide.

3. The method of claim 2 wherein the compound is administered nasally as a solution containing 500 .mu.g of the compound per dose.
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