Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Novartis
Farmers Insurance
Chinese Patent Office
AstraZeneca
Teva
McKesson
Julphar
Fuji
Fish and Richardson
Express Scripts

Generated: August 21, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title: Treatment method
Abstract:A method for inhibiting ovarian steroidogenesis in women comprising administering to women an ovarian steroidogenesis inhibitorilly effective amound of D Ser (tbu).sup.6 des Gly NH.sub.2 .sup.10 LH-RH ethylamide.
Inventor(s): Labrie; Fernand (Quebec, CA), Raynaud; Jean-Pierre (Paris, FR)
Assignee: Uclaf; Roussel (FR)
Filing Date:Nov 30, 1994
Application Number:08/347,054
Claims:1. A method for inhibiting ovarian steroidogenesis in women comprising administering to normal women with regular menstrual cycles an ovarian steroidogenesis inhibitorally effective amount of at least one peptide of the formula

wherein (a) Z is Gly-NH.sub.2, Y is Leu and X is Gly, (b) Z is Gly-NH.sub.2, Y is Leu, X is DN Leu, DN Val, D Abu (.alpha.-aminobutyric acid), D Phe, D Ser, D Thr, D Met, D Pgl, D Lys, Leu, Ile, Nle, Val, N-Val, Met, Phe, D Leu, D Arg, D ser (tbu), D Thr (tbu), D Cys (tbu), D Asp (O tbu), D Glu (Otbu), D Orn (boc), D Lys (boc), D Trp, Trp, 2-methyl Ala, D Tyr, D Met, .epsilon.-lauryl D Lys, .epsilon.-dextran-D Lys, (c) Z is NH-cyclopropyl- or NH-Alk wherein Alk is alkyl of 1 to 3 carbon atoms, Y is Leu and X is D Ser (tbu), D Thr (tbu), D Asp (Otbu), D Glu (Otbu), D Orn (boc), D Lys (boc), (d) Z is --NH--CH.sub.3, --NH--CH.sub.2 --CH.sub.3,--NH--CH.sub.2 --CH.sub.2 --CH.sub.3, --NH--C.H.sub.2 --CH.sub.2 --OH, ##STR2## Y is Leu and X is Gly, (e) Z is --NH--CH.sub.2 --CH.sub.3, Y is Leu and X is D Trp, D Leu, D Ala, D Ser (tbu), D Tyr, D Lys, Ala, (f) Z is Gly-NH.sub.2 or --NH--CH.sub.2 --CH.sub.3, Y is N.alpha.Met Leu and X is Gly (g) Z is --NH-cyclopropyl, Y is Leu and X is D Leu or (h) Z is Gly-NH.sub.2, --NH-cyclopropyl or --NHAlk' where Alk' is alkyl of 1 to 3 carbon atoms, Y is Ser (but), Cys (but), Asp (Obut), Glu (Obut), --Orn (boc), Lys (boc) and X is Gly.

2. A method for inhibiting ovarian steroidogenesis in women comprising administering to women with regular menstrual cycles an ovarian steroidogenesis inhibitorally effective amount of D Ser (tbu).sup.6 des Gly NH.sub.2 .sup.10 LH-RH ethylamide.

3. The method of claim 2 wherein the compound is administered nasally as a solution containing 500 .mu.g of the compound per dose.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Chubb
QuintilesIMS
US Department of Justice
Cantor Fitzgerald
Novartis
Teva
Mallinckrodt
Baxter
Cipla
Queensland Health

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot