Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

McKesson
Daiichi Sankyo
Express Scripts
Cerilliant
Merck
Boehringer Ingelheim
Colorcon
Cantor Fitzgerald
Healthtrust

Generated: April 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,686,464

« Back to Dashboard

Title: 3,3-diphenylpropylamines, their use and preparation
Abstract:A 3,3-diphenylpropylamine of the formula I, or its physiologically acceptable acid salt thereof: ##STR1## wherein R.sup.1 represents hydrogen or methyl, R.sup.2 and R.sup.3 independently represent hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula II ##STR2## wherein R.sup.4 and R.sup.5 independently represent a hydroxy substituted or unsubstituted non-aromatic hydrocarbyl group which can join together to form a ring and which together contain at least three carbon atoms, wherein at least one of R.sup.4 and R.sup.5 is hydroxy substituted, is useful in treating acetylcholine-mediated disorders such as urinary incontinence.
Inventor(s): Johansson; Rolf Arne (Huddinge, SE), Moses; Pinchas (Satsjo-Boo, SE), Nilvebrant; Lisbeth (Bromma, SE), Sparf; Bengt .ANG.ke (Tr.ang.ngsund, SE)
Assignee: Pharmacia AB (Stockholm, SE)
Filing Date:Jul 22, 1996
Application Number:08/684,638
Claims:1. A 3 3-diphenylpropylamine of the formula I: ##STR13## wherein R.sup.1 represents hydrogen or methyl, R.sup.2 and R.sup.3 independently represent hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula II ##STR14## wherein R.sup.4 and R.sup.5 independently represent a hydroxy substituted or unsubstituted non-aromatic hydrocarbyl group which can join together to form a ring and which together contain at least three carbon atoms, wherein at least one of R.sup.4 and R.sup.5 is hydroxy substituted; or a physiologically acceptable acid salt thereof.

2. The 3,3-diphenylpropylamine according to claim 1 wherein R.sup.4 and R.sup.5 are each independently saturated hydroxy substituted or unsubstituted hydrocarbyl groups.

3. The 3,3 -diphenylpropylamine according to claim 1, wherein the HOCH.sub.2 -group is in the 5-position on the phenyl ring, R.sup.2 is hydrogen and R.sup.3 is hydrogen or hydroxy.

4. A pharmaceutical composition comprising an effective amount of a 3,3-diphenylpropylamine according to claim 1 and a compatible pharmaceutical carrier.

5. The 3,3-diphenylpropylamine according to claim 1, wherein said compound is an individual enantiomer.

6. The 3 3-diphenylpropylamine according to claim 2, wherein R.sup.4 and R.sup.5 independently represent a hydroxy substituted or unsubstituted C.sub.1-8 -alkyl group or adamantyl and the total number of carbon atoms contained in R.sup.4 and R.sup.5 is at least four carbon atoms.

7. The 3,3-diphenylpropylamine according to claim 6, wherein R.sup.4 and R.sup.5 independently represent a hydroxy substituted or unsubstituted C.sub.1-6 -alkyl group.

8. The 3,3-diphenylpropylamine according to claim 3, wherein R.sup.3 is in the 2-position on the phenyl ring.

9. A method for treating acetylcholine-mediated disorders which comprises administering to a patient in need thereof an effective amount of a 3,3-diphenylpropylamine as claimed in claim 1.

10. The method according to claim 9, wherein said disorder is urinary incontinence.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Cantor Fitzgerald
Fuji
Covington
Cerilliant
McKinsey
Mallinckrodt
Johnson and Johnson
Daiichi Sankyo
Julphar

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.